CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041272
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Poly (ADP-ribose) polymerase family, member 2, isoform CRA_a 
Protein Synonyms/Alias
 Poly [ADP-ribose] polymerase 2 
Gene Name
 PARP2 
Gene Synonyms/Alias
 hCG_40481 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
276KLTVAQIKAGYQSLKubiquitination[1, 2]
348EIAIKLVKTELQSPEubiquitination[1]
469YFADMSSKSANYCFAubiquitination[2]
480YCFASRLKNTGLLLLubiquitination[2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MAARRRRSTG GGRARALNES KRVNNGNTAP EDSSPAKKTR RCQRQESKKM PVAGGKANKD 60
RTEDKQDGMP GRSWASKRVS ESVKALLLKG KAPVDPECTA KVGKAHVYCE GNDVYDVMLN 120
QTNLQFNNNK YYLIQLLEDD AQRNFSVWMR WGRVGKMGQH SLVACSGNLN KAKEIFQKKF 180
LDKTKNNWED REKFEKVPGK YDMLQMDYAT NTQDEEETKK EESLKSPLKP ESQLDLRVQE 240
LIKLICNVQA MEEMMMEMKY NTKKAPLGKL TVAQIKAGYQ SLKKIEDCIR AGQHGRALME 300
ACNEFYTRIP HDFGLRTPPL IRTQKELSEK IQLLEALGDI EIAIKLVKTE LQSPEHPLDQ 360
HYRNLHCALR PLDHESYEFK VISQYLQSTH APTHSDYTMT LLDLFEVEKD GEKEAFREDL 420
HNRMLLWHGS RMSNWVGILS HGLRIAPPEA PITGYMFGKG IYFADMSSKS ANYCFASRLK 480
NTGLLLLSEV ALGQCNELLE ANPKAEGLLQ GKHSTKGLGK MAPSSAHFVT L 531 
Gene Ontology
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005654; C:nucleoplasm; IEA:Compara.
 GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:Compara.
 GO:0006284; P:base-excision repair; IEA:Compara.
 GO:0006471; P:protein ADP-ribosylation; IEA:InterPro. 
Interpro
 IPR012317; Poly(ADP-ribose)pol_cat_dom.
 IPR004102; Poly(ADP-ribose)pol_reg_dom.
 IPR008893; WGR_domain. 
Pfam
 PF00644; PARP
 PF02877; PARP_reg
 PF05406; WGR 
SMART
 SM00773; WGR 
PROSITE
 PS51060; PARP_ALPHA_HD
 PS51059; PARP_CATALYTIC 
PRINTS