CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034341
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Bdh1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
109GFGFSLAKHLHSKGFacetylation[1, 2]
114LAKHLHSKGFLVFAGacetylation[1, 2]
125VFAGCLMKDKGDAGVacetylation[2]
127AGCLMKDKGDAGVKEacetylation[2]
133DKGDAGVKELDSLKSacetylation[1, 2, 3]
139VKELDSLKSDRLRTIacetylation[1, 3, 4]
139VKELDSLKSDRLRTIsuccinylation[4]
168ETIRSGLKDPEKGMWacetylation[1, 2, 5]
213WGTVRTTKSFLPLLRacetylation[1]
248RSPYCITKFGIEAFSacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice.
 Fritz KS, Galligan JJ, Hirschey MD, Verdin E, Petersen DR.
 J Proteome Res. 2012 Mar 2;11(3):1633-43. [PMID: 22309199]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [5] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 265 AA 
Protein Sequence
MSSGWSIEAL KHLGGFRSLC TRATRRKQSV LQLGATMLAA RLSRPLSQLP GKALSVRDRE 60
NGTRHTLLFY PASFSPDTRR TYASQADAAS GKAILITGCD SGFGFSLAKH LHSKGFLVFA 120
GCLMKDKGDA GVKELDSLKS DRLRTIQLNV CNSEEVEKAV ETIRSGLKDP EKGMWGLVNN 180
AGISTFGEVE FTSMETYKEV AEVNLWGTVR TTKSFLPLLR RAKGRVVNIS SMLGRMANPA 240
RSPYCITKFG IEAFSDCLRY EMHPL 265 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0016491; F:oxidoreductase activity; IEA:InterPro.
 GO:0055114; P:oxidation-reduction process; IEA:GOC. 
Interpro
 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 
Pfam
 PF00106; adh_short 
SMART
  
PROSITE
 PS00061; ADH_SHORT 
PRINTS
 PR00081; GDHRDH.
 PR00080; SDRFAMILY.