CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033900
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Ndufv1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
27KTSFGSLKDEDRIFTacetylation[1, 2]
55LRRGDWYKTKEILLKacetylation[2]
72DWILGEMKTSGLRGRacetylation[1, 2, 3, 4, 5]
72DWILGEMKTSGLRGRsuccinylation[5]
95LKWSFMNKPSDGRPKacetylation[1, 2, 3, 4]
217KQGKPRLKPPFPADVacetylation[2]
356DRSTDIVKAIARLIEacetylation[2]
366ARLIEFYKHESCGQCacetylation[1, 4]
385EGVDWMNKVMARFVKacetylation[2]
392KVMARFVKGDARPAEacetylation[1]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [3] Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice.
 Simon GM, Cheng J, Gordon JI.
 Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11133-8. [PMID: 22733758]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [5] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 455 AA 
Protein Sequence
MLAARHFLGG LVPVRTAPKK TSFGSLKDED RIFTNLYGRH DWRLKGALRR GDWYKTKEIL 60
LKGPDWILGE MKTSGLRGRG GAGFPTGLKW SFMNKPSDGR PKYLVVNADE GEPGTCKDRE 120
IMRHDPHKLV EGCLVGGRAM GARAAYIYIR GEFYNEASNL QVAIREAYEA GLIGKNACGS 180
DYDFDVFVVR GAGAYICGEE TALIESIEGK QGKPRLKPPF PADVGVFGCP TTVANVETVA 240
VSPTICRRGG TWFAGFGRER NSGTKLFNIS GHVNHPCTVE EEMSVPLKEL IEKHAGGVTG 300
GWDNLLAVIP GGSSTPLIPK SVCETVLMDF DALVQAQTGL GTAAVIVMDR STDIVKAIAR 360
LIEFYKHESC GQCTPCREGV DWMNKVMARF VKGDARPAEI DSLWEISKQI EGHTICALGD 420
GAAWPVQGLI RHFRPELEDR MQRFAQQHRA WQAAS 455 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:InterPro.
 GO:0010181; F:FMN binding; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro. 
Interpro
 IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
 IPR019575; NADH-UbQ_OxRdtase_Fsu_4Fe4S-bd.
 IPR011537; NADH-UbQ_OxRdtase_suF.
 IPR011538; NADH_UbQ_OxRdtase_51kDa_su.
 IPR019554; Soluble_ligand-bd. 
Pfam
 PF01512; Complex1_51K
 PF10589; NADH_4Fe-4S
 PF10531; SLBB 
SMART
 SM00928; NADH_4Fe-4S 
PROSITE
 PS00644; COMPLEX1_51K_1
 PS00645; COMPLEX1_51K_2 
PRINTS