UniProt Accession

 DHI1_RAT; P16232; O09170; Q6LDH6 

Genbank Protein ID

 J05107; BC078865; S43333; Y10420; M77835 

Genbank Nucleotide ID

 AAA40886.1; AAH78865.1; AAB22993.1; CAA71447.1; AAA40600.1 

Protein Name

 Corticosteroid 11-beta-dehydrogenase isozyme 1 

Protein Synonyms/Alias

 11-beta-hydroxysteroid dehydrogenase 1; 11-DH; 11-beta-HSD1 

Gene Name

 Hsd11b1 

Gene Synonyms/Alias

 Hsd11 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
69	RSEEGLQKVVSRCLE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes reversibly the conversion of corticosterone to 11-dehydrocorticosterone. 

Sequence Annotation

 NP_BIND 37 63 NADP (By similarity).
 NP_BIND 88 89 NADP (By similarity).
 NP_BIND 115 117 NADP (By similarity).
 NP_BIND 179 183 NADP (By similarity).
 NP_BIND 212 218 NADP (By similarity).
 ACT_SITE 179 179 Proton acceptor (By similarity).
 BINDING 166 166 Substrate (By similarity).
 CARBOHYD 158 158 N-linked (GlcNAc...) (Potential).
 CARBOHYD 203 203 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative promoter usage; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Lipid metabolism; Membrane; NADP; Oxidoreductase; Reference proteome; Signal-anchor; Steroid metabolism; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0045177; C:apical part of cell; IDA:RGD.
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031965; C:nuclear membrane; IDA:RGD.
 GO:0005791; C:rough endoplasmic reticulum; IDA:RGD.
 GO:0070524; F:11-beta-hydroxysteroid dehydrogenase (NADP+) activity; IEA:EC.
 GO:0003845; F:11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity; IDA:RGD.
 GO:0050661; F:NADP binding; IDA:RGD.
 GO:0005496; F:steroid binding; IPI:RGD.
 GO:0071392; P:cellular response to estradiol stimulus; IEP:RGD.
 GO:0006704; P:glucocorticoid biosynthetic process; IDA:RGD.
 GO:0006713; P:glucocorticoid catabolic process; IDA:RGD.
 GO:0018963; P:phthalate metabolic process; IEP:RGD.
 GO:0043456; P:regulation of pentose-phosphate shunt; IDA:RGD.
 GO:0031667; P:response to nutrient levels; IEP:RGD. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

 PF00106; adh_short 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.