CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042950
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Fermitin family homolog 2 
Protein Synonyms/Alias
  
Gene Name
 FERMT2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
238SFFDLNPKYDAIRINacetylation[1]
238SFFDLNPKYDAIRINubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 640 AA 
Protein Sequence
SDHALWWEKK RTWLLKTHWT LDKYGIQADA KLQFTPQHKL LRLQLPNMKY VKVKVNFSDR 60
VFKAVSDICK TFNIRHPEEL SLLKKPRDPT KKKKKKLDDQ SEDEALELEG PLITPGSGTD 120
VLYIGPLKGS IYSSPGLYSK TMTPTYDAHD GSPLSPTSAW FGDSALSEGN PGILAVSQPI 180
TSPEILAKMF KPQALLDKAK INQGWLDSSR SLMEQDVKEN EALLLRFKYY SFFDLNPKYD 240
AIRINQLYEQ AKWAILLEEI ECTEEEMMMF AALQYHINKL SIMTSENHLN NSDKEVDEVD 300
AALSDLEITL EGGKTSTILG DITSIPELAD YIKVFKPKKL TLKGYKQYWC TFKDTSISCY 360
KSKEESSGTP AHQMNLRGCE VTPDVNISGQ KFNIKLLIPV AEGMNEIWLR CDNEKQYAHW 420
MAACRLASKG KTMADSSYNL EVQNILSFLK MQHLNPDPQL IPEQITTDIT PECLVSPRYL 480
KKYKNKQPGY IRDLITARIL EAHQNVAQMS LIEAKMRFIQ AWQSLPEFGI THFIARFQGG 540
KKEELIGIAY NRLIRMDAST GDAIKTWRFS NMKQWNVNWE IKMVTVEFAD EVRLSFICTE 600
VDCKVVHEFI GGYIFLSTRA KDQNESLDEE MFYKLTSGWV 640 
Gene Ontology
 GO:0005925; C:focal adhesion; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005543; F:phospholipid binding; IEA:InterPro. 
Interpro
 IPR019749; Band_41_domain.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR018979; FERM_N.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology. 
Pfam
 PF00373; FERM_M
 PF09379; FERM_N
 PF00169; PH 
SMART
 SM00295; B41
 SM00233; PH 
PROSITE
 PS50003; PH_DOMAIN 
PRINTS