CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033573
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Sodium bicarbonate cotransporter 3 
Protein Synonyms/Alias
  
Gene Name
 SLC4A7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
23EAVVDLGKTSSTVNTubiquitination[1]
31TSSTVNTKFEKEELEubiquitination[1, 2]
34TVNTKFEKEELESHRubiquitination[2]
130DGEEYEWKETARWLKubiquitination[1, 2]
137KETARWLKFEEDVEDubiquitination[2]
267PGNLDNSKSGEIKGNubiquitination[1, 2, 3]
373LLLGPAGKAPQYHEIubiquitination[1]
399IFHDVAYKAKDRNDLubiquitination[2, 3]
401HDVAYKAKDRNDLLSubiquitination[4]
435SIRIEPPKSVPSQEKubiquitination[2]
442KSVPSQEKRKIPVFHubiquitination[1, 2]
444VPSQEKRKIPVFHNGubiquitination[2]
461PTLGETPKEAAHHAGubiquitination[1]
486GGLILDIKRKAPFFLubiquitination[2, 3, 4]
680ETLAQWKKDNITAHNubiquitination[2]
962KLFGMPAKHQPDLIYubiquitination[2, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1051 AA 
Protein Sequence
MERFRLEKKL PGPDEEAVVD LGKTSSTVNT KFEKEELESH RAVYIGVHVP FSKESRRRHR 60
HRGHKHHHRR RKDKESDKED GRESPSYDTP SQRVQFILGT EDDDEEHIPH DLFTEMDELC 120
YRDGEEYEWK ETARWLKFEE DVEDGGDRWS KPYVATLSLH SLFELRSCIL NGTVMLDMRA 180
STLDEIADMV LDNMIASGQL DESIRENVRE ALLKRHHHQN EKRFTSRIPL VRSFADIGKK 240
HSDPHLLERN GILASPQSAP GNLDNSKSGE IKGNGSGGSR ENSTVDFSKE SASWHCSCGT 300
LGVGLKRPAV DMNFMRKIPT GAEASNVLVG EVDFLERPII AFVRLAPAVL LTGLTEVPVP 360
TRFLFLLLGP AGKAPQYHEI GRSIATLMTD EIFHDVAYKA KDRNDLLSGI DEFLDQVTVL 420
PPGEWDPSIR IEPPKSVPSQ EKRKIPVFHN GSTPTLGETP KEAAHHAGPE LQRTGRLFGG 480
LILDIKRKAP FFLSDFKDAL SLQCLASILF LYCACMSPVI TFGGLLGEAT EGRISAIESL 540
FGASLTGIAY SLFAGQPLTI LGSTGPVLVF EKILYKFCRD YQLSYLSLRT SIGLWTSFLC 600
IVLVATDASS LVCYITRFTE EAFAALICII FIYEALEKLF DLGETYAFNM HNNLDKLTSY 660
SCVCTEPPNP SNETLAQWKK DNITAHNISW RNLTVSECKK LRGVFLGSAC GHHGPYIPDV 720
LFWCVILFFT TFFLSSFLKQ FKTKRYFPTK VRSTISDFAV FLTIVIMVTI DYLVGVPSPK 780
LHVPEKFEPT HPERGWIISP LGDNPWWTLL IAAIPALLCT ILIFMDQQIT AVIINRKEHK 840
LKKGAGYHLD LLMVGVMLGV CSVMGLPWFV AATVLSISHV NSLKVESECS APGEQPKFLG 900
IREQRVTGLM IFILMGLSVF MTSVLKFIPM PVLYGVFLYM GVSSLKGIQL FDRIKLFGMP 960
AKHQPDLIYL RYVPLWKVHI FTVIQLTCLV LLWVIKVSAA AVVFPMMVLA LVFVRKLMDL 1020
CFTKRELSWL DDLMPESKKK KEDDKKKKEK E 1051 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005452; F:inorganic anion exchanger activity; IEA:InterPro. 
Interpro
 IPR013769; Band3_cytoplasmic_dom.
 IPR011531; HCO3_transpt_C.
 IPR003020; HCO3_transpt_euk.
 IPR003024; Na/HCO3_transpt.
 IPR016152; PTrfase/Anion_transptr. 
Pfam
 PF07565; Band_3_cyto
 PF00955; HCO3_cotransp 
SMART
  
PROSITE
  
PRINTS
 PR01231; HCO3TRNSPORT.
 PR01232; NAHCO3TRSPRT.