| Tag | Content |
|---|
| CPLM ID | CPLM-021035 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Solute carrier organic anion transporter family member 1A4 |
Protein Synonyms/Alias | Sodium-independent organic anion-transporting polypeptide 2; Solute carrier family 21 member 5 |
Gene Name | Slco1a4 |
Gene Synonyms/Alias | Oatp1a4; Oatp2; Slc21a5 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 272 | FFPKTLLKEGLQDNG | ubiquitination | [1] | | 289 | TENAKEEKHREKIKE | ubiquitination | [1] | | 643 | DTDPAEMKLTAKESK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, estrone-3-sulfate, the cardiac glycosides ouabain and digoxin and thyroid hormones (By similarity). |
Sequence Annotation | DOMAIN 433 488 Kazal-like.
CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
CARBOHYD 135 135 N-linked (GlcNAc...) (Potential).
CARBOHYD 483 483 N-linked (GlcNAc...) (Potential).
CARBOHYD 492 492 N-linked (GlcNAc...) (Potential).
DISULFID 439 465 By similarity.
DISULFID 443 454 By similarity.
DISULFID 445 469 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Ion transport; Membrane; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 670 AA |
Protein Sequence | MGKSEKEVAT HGVRCFSKIK AFLLALTCAY VSKSLSGTYM NSMLTQIERQ FGIPTSVVGL 60
INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCAVMGLGC FLISIPHFLM GRYEYETTIL 120
PTSNLSSNSF VCTENRTQTL KPTQDPTECV KEMKSLMWIY VLVGNIIRGM GETPIMPLGI 180
SYIEDFAKSE NSPLYIGILE TGMTIGPLIG LLLGSSCANI YVDTGSVNTD DLTITPTDTR 240
WVGAWWIGFL VCAGVNILTS IPFFFFPKTL LKEGLQDNGD GTENAKEEKH REKIKEENRG 300
ITKDFFLFMK SLSCNPIYMI FILISVIQVN AFINSFTFMP KYLEQQYGKS TAEIVFLMGL 360
YMLPPICLGY LIGGLIMKKF KITVKKAAYI GFWLSLTEYL LSFVSYIMTC DNFPVAGLTT 420
SYEGVQHPLY VENNVLADCN TKCSCLTNTW DPVCGDNGLS YMSACLAGCE KSVGTGTNMV 480
FQNCSCIQSS GNASAVLGLC DKGPECANKL QYFLIISIIG CFIFSLGAIP GYMVLLRCMK 540
SEEKSLGVGL HTFCMRILGG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYDINSFRRI 600
YLGLPAALRG ASFLPALFIL ILMRKFQFPG DIDSSDTDPA EMKLTAKESK CTNVHRSPTM 660
QNDGERKTKL 670 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0016020; C:membrane; IDA:MGI. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0015125; F:bile acid transmembrane transporter activity; IEA:Compara. GO:0008514; F:organic anion transmembrane transporter activity; IDA:MGI. GO:0043252; P:sodium-independent organic anion transport; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |