UniProt Accession

 FBRL_DROME; Q9W1V3; Q24348; Q8IGK5 

Genbank Protein ID

 AE013599; BT001738; X05285 

Genbank Nucleotide ID

 AAF46950.1; AAN71493.1; CAA28903.1 

Protein Name

 rRNA 2'-O-methyltransferase fibrillarin 

Protein Synonyms/Alias

  

Gene Name

 Fib 

Gene Synonyms/Alias

 CG9888 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
109	AGGFKGGKTVTIEPH	acetylation	[1]
146	GSEVYGEKRISVETN	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). 

Sequence Annotation

 REGION 197 198 S-adenosyl-L-methionine binding (By
 REGION 216 217 S-adenosyl-L-methionine binding (By
 REGION 241 242 S-adenosyl-L-methionine binding (By
 BINDING 168 168 S-adenosyl-L-methionine (By similarity).
 BINDING 261 261 S-adenosyl-L-methionine (By similarity).
 MOD_RES 9 9 Asymmetric dimethylarginine (By
 MOD_RES 23 23 Asymmetric dimethylarginine (By
 MOD_RES 25 25 Asymmetric dimethylarginine (By
 MOD_RES 40 40 Asymmetric dimethylarginine (By
 MOD_RES 42 42 Asymmetric dimethylarginine (By
 MOD_RES 48 48 Asymmetric dimethylarginine (By
 MOD_RES 51 51 Asymmetric dimethylarginine (Probable).
 MOD_RES 58 58 Asymmetric dimethylarginine (Probable).
 MOD_RES 63 63 Asymmetric dimethylarginine (Probable).
 MOD_RES 71 71 Asymmetric dimethylarginine (Probable).
 MOD_RES 77 77 Asymmetric dimethylarginine (Probable).
 MOD_RES 83 83 Asymmetric dimethylarginine (Probable).
 MOD_RES 88 88 Asymmetric dimethylarginine (Probable).
 MOD_RES 93 93 Asymmetric dimethylarginine (Probable).
 MOD_RES 98 98 Asymmetric dimethylarginine (Probable).  

Keyword

 Complete proteome; Methylation; Methyltransferase; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; rRNA processing; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 344 AA 

Protein Sequence

Gene Ontology

 GO:0015030; C:Cajal body; IDA:FlyBase.
 GO:0001651; C:dense fibrillar component; ISS:UniProtKB.
 GO:0030532; C:small nuclear ribonucleoprotein complex; ISS:FlyBase.
 GO:0005732; C:small nucleolar ribonucleoprotein complex; ISS:FlyBase.
 GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0051297; P:centrosome organization; IMP:FlyBase.
 GO:0006396; P:RNA processing; ISS:UniProtKB.
 GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
 GO:0008033; P:tRNA processing; IEA:InterPro. 

Interpro

 IPR000692; Fibrillarin.
 IPR020813; Fibrillarin_CS. 

Pfam

 PF01269; Fibrillarin 

SMART

  

PROSITE

 PS00566; FIBRILLARIN 

PRINTS

 PR00052; FIBRILLARIN.