UniProt Accession

 BSCL2_HUMAN; Q96G97; G3XAE4; Q567S1; Q96SV1; Q9BSQ0 

Genbank Protein ID

 AK027524; AK075317; AF052149; CH471076; CH471076; AP001458; BC004911; BC012140; BC041640; BC093048 

Genbank Nucleotide ID

 BAB55175.1; BAC11543.1; EAW74070.1; EAW74074.1; AAH04911.1; AAH12140.1; AAH41640.1; AAH93048.1 

Protein Name

 Seipin 

Protein Synonyms/Alias

 Bernardinelli-Seip congenital lipodystrophy type 2 protein 

Gene Name

 BSCL2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
93	VANVSLTKGGRDRVL	ubiquitination	[1, 2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Is a regulator of lipid catabolism essential for adipocyte differentiation. May also be involved in the central regulation of energy homeostasis (By similarity). Necessary for correct lipid storage and lipid droplets maintenance; may play a tissue-autonomous role in controlling lipid storage in adipocytes and in preventing ectopic lipid droplet formation in non-adipose tissues. 

Sequence Annotation

 CARBOHYD 88 88 N-linked (GlcNAc...).
 CARBOHYD 242 242 N-linked (GlcNAc...) (Potential).  

Keyword

 Alternative splicing; Complete proteome; Congenital generalized lipodystrophy; Diabetes mellitus; Disease mutation; Endoplasmic reticulum; Glycoprotein; Hereditary spastic paraplegia; Lipid degradation; Lipid metabolism; Membrane; Neurodegeneration; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 398 AA 

Protein Sequence

Gene Ontology

 GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0045444; P:fat cell differentiation; ISS:UniProtKB.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0034389; P:lipid particle organization; IMP:UniProtKB.
 GO:0019915; P:lipid storage; IMP:UniProtKB.
 GO:0050995; P:negative regulation of lipid catabolic process; ISS:UniProtKB. 

Interpro

 IPR009617; Adipose-reg_protein_Seipin. 

Pfam

 PF06775; Seipin 

SMART

  

PROSITE

  

PRINTS