UniProt Accession

 ZN444_HUMAN; Q8N0Y2; Q8TEQ9; Q8WU35; Q9NUU1 

Genbank Protein ID

 AB052955; AB052954; AL834130; AK074063; AK001999; BC021282 

Genbank Nucleotide ID

 BAC02698.1; BAC02697.1; CAD38847.1; BAB84889.1; BAA92028.1; AAH21282.1 

Protein Name

 Zinc finger protein 444 

Protein Synonyms/Alias

 Endothelial zinc finger protein 2; EZF-2; Zinc finger and SCAN domain-containing protein 17 

Gene Name

 ZNF444 

Gene Synonyms/Alias

 EZF2; ZSCAN17 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
8	MEVAVPVKQEAEGLA	sumoylation	[1]
8	MEVAVPVKQEAEGLA	ubiquitination	[2]

Reference

 [1] Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions.
 Lamoliatte F, Bonneil E, Durette C, Caron-Lizotte O, Wildemann D, Zerweck J, Wenschuh H, Thibault P.
 Mol Cell Proteomics. 2013 Jun 7;. [PMID: 23750026]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Transcriptional regulator. Binds to the 5'-flanking critical region of the SCARF1 promoter. 

Sequence Annotation

 DOMAIN 20 104 SCAN box.
 ZN_FING 179 201 C2H2-type 1.
 ZN_FING 207 229 C2H2-type 2.
 ZN_FING 250 272 C2H2-type 3.
 ZN_FING 278 300 C2H2-type 4.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 18 18 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0000981; F:sequence-specific DNA binding RNA polymerase II transcription factor activity; IBA:RefGenome.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0016032; P:viral reproduction; IEA:InterPro. 

Interpro

 IPR008916; Retrov_capsid_C.
 IPR003309; Tscrpt_reg_SCAN.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF02023; SCAN 

SMART

 SM00431; SCAN
 SM00355; ZnF_C2H2 

PROSITE

 PS50804; SCAN_BOX
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS