Tag | Content |
---|
CPLM ID | CPLM-015069 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | A-kinase anchor protein SPHKAP |
Protein Synonyms/Alias | SPHK1-interactor and AKAP domain-containing protein |
Gene Name | Sphkap |
Gene Synonyms/Alias | Kiaa1678 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
1332 | EALMRKNKIIADDSE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1 (By similarity). |
Sequence Annotation | REGION 914 931 PKA-RII subunit binding domain (By |
Keyword | Alternative splicing; Complete proteome; Cytoplasm; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1687 AA |
Protein Sequence | MSTPGFLCKA MWVVEPNSAT CLSAALPVKR HCQESSNVES PLMHEGPEPQ QITSSAAGNL 60 AGSITACKKV LRSNSLLEST DYWLQNQRTP CQIGFVEDES ENCASVCFVN LDVNKDACIT 120 ENLQQKLVNV SPDLPNLISS MNVQQPKENE IVLLSGLASG NPQADFDVSQ CPWLPDICLV 180 QCARGNRPNS TNCIIFEINK FLIGLEVVQE RQLHLETNVL KLEDDTNCSL SSIEEDFLTA 240 SEHLEEEIEV DDCRSGLENT NVSANVLESK KPKETTQEGW DYHKEKLHCA LGEKHIRKHR 300 TPSTKTEGSK ENTEENTSLK SLNRLVRPSH LKSEVAGNKQ LATNYSYPEN IKGELETSQM 360 LFIPRDAYLS MVKKDVLSPC SVLSEQGGSH RDHDVTPNPL PPVQNGEAST GEYATNLAES 420 VMQDAFIRLS QSQPTLPQES AVSFSMRSAL LPSGCCTKDM VVPRSWNELP KIVIVQSPDG 480 SDTVPEPNVS SWPDMEFVET SGIFSADSSS RPTQSALEVA LACAATVIGT ISSPQATERF 540 AMEQESLVST YAQRGTGVQQ TQVPQAFMAP STTEYSFPSA LCGMTQVASA VAVCGLCEKE 600 EATCPVAPTD LLPTSGASEE ISSIGSLVME RSTELGKEAI AEALLREATL ILARPDAYSS 660 LGELLESVNQ RIIETTSKTQ TLCTESVQRN ELAHTLSNVI LKHSVDELHQ KTTMAHPTDE 720 RHPCGTLDTL MESVNQLLHN VICFTFKKMN HIVTLSEHPS FDQAAGQAWV KAFACPSSQP 780 LSNAHGTGLV IRNLVEDASP KSNKGGARPE LVNNPRLQSE FSCSHRMFDS TAKSFPKEIY 840 LKGIMGEDTR NPHHTLNYDS NERRASTDLG KLTTASEGCS GFQETEDSIV PNTQEKYICA 900 TPLNNEAQVN LSLLGDDLSV PAQSTLEAKQ SEVYGITDFA EELAETVVSM ATEIAAICLD 960 NSNGKQPWFC AWKRGNEFLT APNGSCRSLK RKKENSSAGS TVRKHKPPRL SEIKRKADEH 1020 PELKEKLMNR VMDESMNLED IPDSVSTFAN EVAAKIMNLT EFSMVDGVWQ GQSCSRTRLL 1080 GGDRWNRLKA SSCESIPEED SEARVFVNSL GLMSTLSQPV SRASSVSKQS SCESITDEFS 1140 RFMVKQMENE GRGFELLLDY YAGKNASSIM SSAMQQACQK NDHLNVRPSC PSKQSSTESI 1200 TEEFYRYMLR DIAKESKDGA SSRRSSHDWT TGLLSPSTRS PLCYRQSSMP DSRSPCSRLT 1260 VNAPVKANSL DGFAQNCPQD SVNVQPVSRA SSSGLCKSDS CLYRRSGTDQ ITNMLIHETW 1320 ASSIEALMRK NKIIADDSEA ANASPGPVSS GSPLQVEKNA NRLATSKGHR GPTLLVQESV 1380 DYQRKDAVTE GNHSPVSSPG KTAPVKKPSD FDPRRETSAC HNAAGLNSPR RSLCSRDVPL 1440 IQIETDQKEE CIGEPGPFLS QSGSLEETEG HQPEETIPDV ARNEDTAPST CQSSRDSLET 1500 SGEVEVEVLK EDIPRDESRN PPSSSEESTG SWSQLANEED IPDDTSSFLQ LSERSMSNGN 1560 SSGTSSLGIM DLDIYQESIP SSPMINELVE EKEILKEQSE SIKEHASGLP GRAASPQRSL 1620 LVINFDLEPE CPDAELRATL QWIAASELGI PTIYFKKSQE SRIEKFLDVV KLVQQKSWKV 1680 GDIFHAVVQY CKLHAEQKER TPSLFDWLLE LG 1712 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |