CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031829
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Elongation factor 1-alpha 
Protein Synonyms/Alias
  
Gene Name
 TGGT1_037840, TGGT1_075120, TgIa.0820, TGME49_086420,TGME49_094800, TGVEG_013060, TGVEG_033650 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Toxoplasma gondii 
NCBI Taxa ID
 5811 
Lysine Modification
Position
Peptide
Type
References
41IDKRTIEKFEKESSEacetylation[1, 2]
44RTIEKFEKESSEMGKacetylation[1, 2]
210STNMSWYKGKTLVEAacetylation[1, 2]
241LPLQDVYKIGGIGTVacetylation[1]
316GYVASDSKNDPAKGCacetylation[1]
362ACKFAEIKTKMDKRSacetylation[1, 2]
378KTLEEAPKCIKSGDAacetylation[1, 2]
425TVAVGVIKSVEKKEPacetylation[1]
Reference
 [1] Lysine acetylation is widespread on proteins of diverse function and localization in the protozoan parasite Toxoplasma gondii.
 Jeffers V, Sullivan WJ Jr.
 Eukaryot Cell. 2012 Jun;11(6):735-42. [PMID: 22544907]
 [2] Protein intrinsic disorder in the acetylome of intracellular and extracellular Toxoplasma gondii.
 Xue B, Jeffers V, Sullivan WJ, Uversky VN.
 Mol Biosyst. 2013 Apr 5;9(4):645-57. [PMID: 23403842] 
Functional Description
 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Elongation factor; GTP-binding; Nucleotide-binding; Nucleotidyltransferase; Protein biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
MGKEKTHINL VVIGHVDSGK STTTGHLIYK LGGIDKRTIE KFEKESSEMG KGSFKYAWVL 60
DKLKAERERG ITIDIALWQF ETPKYHYTVI DAPGHRDFIK NMITGTSQAD VALLVVPAEA 120
GGFEGAFSKE GQTREHALLA FTLGVKQMIV GINKMDSCNY SEDRFNEIQK EVAMYLKKVG 180
YNPEKVPFVA ISGFVGDNMV EKSTNMSWYK GKTLVEALDT MEAPKRPSDK PLRLPLQDVY 240
KIGGIGTVPV GRVETGILKA GMVLTFAPVG LTTECKSVEM HHEVMEQAVP GDNVGFNVKN 300
VSVKELKRGY VASDSKNDPA KGCATFLAQV IVLNHPGEIK NGYSPVIDCH TAHIACKFAE 360
IKTKMDKRSG KTLEEAPKCI KSGDAAMVNM EPSKPMVVEA FTDYPPLGRF AVRDMKQTVA 420
VGVIKSVEKK EPGAGSKVTK SAVKAAKK 448 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
 GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR000795; EF_GTP-bd_dom.
 IPR027417; P-loop_NTPase.
 IPR009001; Transl_elong_EF1A/Init_IF2_C.
 IPR004539; Transl_elong_EF1A_euk/arc.
 IPR004161; Transl_elong_EFTu/EF1A_2.
 IPR004160; Transl_elong_EFTu/EF1A_C.
 IPR009000; Transl_elong_init/rib_B-barrel. 
Pfam
 PF00009; GTP_EFTU
 PF03144; GTP_EFTU_D2
 PF03143; GTP_EFTU_D3 
SMART
  
PROSITE
 PS00301; EFACTOR_GTP 
PRINTS
 PR00315; ELONGATNFCT.