CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030050
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Myosin heavy chain 11 smooth muscle isoform 
Protein Synonyms/Alias
  
Gene Name
 MYH11 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
83IQKMNPPKFSKVEDMubiquitination[1]
239LEAFGNAKTVKNDNSubiquitination[1]
774LYRIGQSKIFFRTGVubiquitination[1]
1233KANLDKNKQTLEKENubiquitination[2]
1459NLEKKQRKFDQLLAEubiquitination[1]
1491EAREKETKALSLARAubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Motor protein; Myosin; Nucleotide-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2029 AA 
Protein Sequence
MAQKGQLSDD EKFLFVDKNF INSPVAQADW AAKRLVWVPS EKQGFEAASI KEEKGDEVVV 60
ELVENGKKVT VGKDDIQKMN PPKFSKVEDM AELTCLNEAS VLHNLRERYF SGLIYTYSGL 120
FCVVVNPYKH LPIYSEKIVD MYKGKKRHEM PPHIYAIADT AYRSMLQDRE DQSILCTGES 180
GAGKTENTKK VIQYLAVVAS SHKGKKDTSI TEGPSFWRGE LEKQLLQANP ILEAFGNAKT 240
VKNDNSSRFG KFIRINFDVT GYIVGANIET YLLEKSRAIR QARDERTFHI FYYMIAGAKE 300
KMRSDLLLEG FNNYTFLSNG FVPIPAAQDD EMFQETVEAM AIMGFSEEEQ LSILKVVSSV 360
LQLGNIVFKK ERNTDQASMP DNTAAQKVCH LMGINVTDFT RSILTPRIKV GRDVVQKAQT 420
KEQADFAVEA LAKATYERLF RWILTRVNKA LDKTHRQGAS FLGILDIAGF EIFEVNSFEQ 480
LCINYTNEKL QQLFNHTMFI LEQEEYQREG IEWNFIDFGL DLQPCIELIE RPNNPPGVLA 540
LLDEECWFPK ATDKSFVEKL CTEQGSHPKF QKPKQLKDKT EFSIIHYAGK VDYNASAWLT 600
KNMDPLNDNV TSLLNASSDK FVADLWKDVD RIVGLDQMAK MTESSLPSAS KTKKGMFRTV 660
GQLYKEQLGK LMTTLRNTTP NFVRCIIPNH EKRSGKLDAF LVLEQLRCNG VLEGIRICRQ 720
GFPNRIVFQE FRQRYEILAA NAIPKGFMDG KQACILMIKA LELDPNLYRI GQSKIFFRTG 780
VLAHLEEERD LKITDVIMAF QAMCRGYLAR KAFAKRQQQL TAMKVIQRNC AAYLKLRNWQ 840
WWRLFTKVKP LLQVTRQEEE MQAKEDELQK TKERQQKAEN ELKELEQKHS QLTEEKNLLQ 900
EQLQAETELY AEAEEMRVRL AAKKQELEEI LHEMEARLEE EEDRGQQLQA ERKKMAQQML 960
DLEEQLEEEE AARQKLQLEK VTAEAKIKKL EDEILVMDDQ NNKLSKERKL LEERISDLTT 1020
NLAEEEEKAK NLTKLKNKHE SMISELEVRL KKEEKSRQEL EKLKRKLEGD ASDFHEQIAD 1080
LQAQIAELKM QLAKKEEELQ AALARLDDEI AQKNNALKKI RELEGHISDL QEDLDSERAA 1140
RNKAEKQKRD LGEELEALKT ELEDTLDSTA TQQELRAKRE QEVTVLKKAL DEETRSHEAQ 1200
VQEMRQKHAQ AVEELTEQLE QFKRAKANLD KNKQTLEKEN ADLAGELRVL GQAKQEVEHK 1260
KKKLEAQVQE LQSKCSDGER ARAELNDKVH KLQNEVESVT GMLNEAEGKA IKLAKDVASL 1320
SSQLQDTQEL LQEETRQKLN VSTKLRQLEE ERNSLQDQLD EEMEAKQNLE RHISTLNIQL 1380
SDSKKKLQDF ASTVEALEEG KKRFQKEIEN LTQQYEEKAA AYDKLEKTKN RLQQELDDLV 1440
VDLDNQRQLV SNLEKKQRKF DQLLAEEKNI SSKYADERDR AEAEAREKET KALSLARALE 1500
EALEAKEELE RTNKMLKAEM EDLVSSKDDV GKNVHELEKS KRALETQMEE MKTQLEELED 1560
ELQATEDAKL RLEVNMQALK GQFERDLQAR DEQNEEKRRQ LQRQLHEYET ELEDERKQRA 1620
LAAAAKKKLE GDLKDLELQA DSAIKGREEA IKQLRKLQAQ MKDFQRELED ARASRDEIFA 1680
TAKENEKKAK SLEADLMQLQ EDLAAAERAR KQADLEKEEL AEELASSLSG RNALQDEKRR 1740
LEARIAQLEE ELEEEQGNME AMSDRVRKAT QQAEQLSNEL ATERSTAQKN ESARQQLERQ 1800
NKELRSKLHE MEGAVKSKFK STIAALEAKI AQLEEQVEQE AREKQAATKS LKQKDKKLKE 1860
ILLQVEDERK MAEQYKEQAE KGNARVKQLK RQLEEAEEES QRINANRRKL QRELDEATES 1920
NEAMGREVNA LKSKLRGPPH RKLRSDAPGE ETRPLSFLLE GLEDVELLKM QMVLRRKRTL 1980
ETQTSMEPRP VNKQLSTVLH HGKKTKNQNK QTKKTQQQPR TKQNPADCT 2029 
Gene Ontology
 GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.