| Tag | Content |
|---|
| CPLM ID | CPLM-011891 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Structural maintenance of chromosomes protein 6 |
Protein Synonyms/Alias | DNA repair protein RHC18; Rad18 homolog |
Gene Name | SMC6 |
Gene Synonyms/Alias | RHC18; YLR383W; L3502.2 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 702 | DNGTQYLKDLIEQET | ubiquitination | [1] |
|
Reference | [1] Identification, analysis, and prediction of protein ubiquitination sites. Radivojac P, Vacic V, Haynes C, Cocklin RR, Mohan A, Heyen JW, Goebl MG, Iakoucheva LM. Proteins. 2010 Feb 1;78(2):365-80. [ PMID: 19722269] |
Functional Description | Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks. Probably plays a role in structure. |
Sequence Annotation | NP_BIND 109 116 ATP (Potential).
REGION 530 695 Flexible hinge.
MOTIF 35 39 Nuclear localization signal (Potential). |
Keyword | ATP-binding; Chromosome; Coiled coil; Complete proteome; DNA damage; DNA recombination; DNA repair; Nucleotide-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1114 AA |
Protein Sequence | MISTTISGKR PIEQVDDELL SLTAQQENEE QQQQRKRRRH QFAPMTQFNS NTLDEDSGFR 60
SSSDVATADQ DNFLEESPSG YIKKVILRNF MCHEHFELEL GSRLNFIVGN NGSGKSAILT 120
AITIGLGAKA SETNRGSSLK DLIREGCYSA KIILHLDNSK YGAYQQGIFG NEIIVERIIK 180
RDGPASFSLR SENGKEISNK KKDIQTVVDY FSVPVSNPMC FLSQDAARSF LTASTSQDKY 240
SHFMKGTLLQ EITENLLYAS AIHDSAQENM ALHLENLKSL KAEYEDAKKL LRELNQTSDL 300
NERKMLLQAK SLWIDVAHNT DACKNLENEI SGIQQKVDEV TEKIRNRQEK IERYTSDGTT 360
IEAQIDAKVI YVNEKDSEHQ NARELLRDVK SRFEKEKSNQ AEAQSNIDQG RKKVDALNKT 420
IAHLEEELTK EMGGDKDQMR QELEQLEKAN EKLREVNNSL VVSLQDVKNE ERDIQHERES 480
ELRTISRSIQ NKKVELQNIA KGNDTFLMNF DRNMDRLLRT IEQRKNEFET PAIGPLGSLV 540
TIRKGFEKWT RSIQRAISSS LNAFVVSNPK DNRLFRDIMR SCGIRSNIPI VTYCLSQFDY 600
SKGRAHGNYP TIVDALEFSK PEIECLFVDL SRIERIVLIE DKNEARNFLQ RNPVNVNMAL 660
SLRDRRSGFQ LSGGYRLDTV TYQDKIRLKV NSSSDNGTQY LKDLIEQETK ELQNIRDRYE 720
EKLSEVRSRL KEIDGRLKST KNEMRKTNFR MTELKMNVGK VVDTGILNSK INERKNQEQA 780
IASYEAAKEE LGLKIEQIAQ EAQPIKEQYD STKLALVEAQ DELQQLKEDI NSRQSKIQKY 840
KDDTIYYEDK KKVYLENIKK IEVNVAALKE GIQRQIQNAC AFCSKERIEN VDLPDTQEEI 900
KRELDKVSRM IQKAEKSLGL SQEEVIALFE KCRNKYKEGQ KKYMEIDEAL NRLHNSLKAR 960
DQNYKNAEKG TCFDADMDFR ASLKVRKFSG NLSFIKDTKS LEIYILTTND EKARNVDTLS 1020
GGEKSFSQMA LLLATWKPMR SRIIALDEFD VFMDQVNRKI GTTLIVKKLK DIARTQTIII 1080
TPQDIGKIAD IDSSGVSIHR MRDPERQNNS NFYN 1114 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
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