UniProt Accession

 DHRS4_RAT; Q8VID1; Q6IRD4 

Genbank Protein ID

 CH474049; BC070961; AB062758 

Genbank Nucleotide ID

 EDM14225.1; AAH70961.1; BAB78529.1 

Protein Name

 Dehydrogenase/reductase SDR family member 4 

Protein Synonyms/Alias

 NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase; CR; PHCR; NADPH-dependent retinol dehydrogenase/reductase; NDRD; Peroxisomal short-chain alcohol dehydrogenase; PSCD 

Gene Name

 Dhrs4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
93	GVVCHVGKAEDREKL	acetylation	[1]
99	GKAEDREKLVNMALK	acetylation	[1]
159	AVVPAMEKRGGGSVV	acetylation	[1]
204	FAAELAPKNIRVNCL	acetylation	[1]
226	HFSSVLWKEKAREEM	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). 

Sequence Annotation

 NP_BIND 37 61 NADP (By similarity).
 MOTIF 277 279 Microbody targeting signal.
 ACT_SITE 183 183 Proton acceptor (By similarity).
 BINDING 170 170 Substrate (By similarity).  

Keyword

 Complete proteome; NADP; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; ISS:UniProtKB.
 GO:0005777; C:peroxisome; IDA:RGD.
 GO:0004090; F:carbonyl reductase (NADPH) activity; IEA:EC.
 GO:0001758; F:retinal dehydrogenase activity; IEA:Compara.
 GO:0042574; P:retinal metabolic process; IEA:Compara. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR027052; DHRS2/4.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR020904; Sc_DH/Rdtase_CS. 

Pfam

  

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.
 PR00080; SDRFAMILY.