UniProt Accession

 PGAM5_HUMAN; Q96HS1; A9LN06; C9IZY7; Q96JB0 

Genbank Protein ID

 EU249757; AC135586; BC008196; AF357523 

Genbank Nucleotide ID

 ABX39494.1; AAH08196.1; AAK60627.1 

Protein Name

 Serine/threonine-protein phosphatase PGAM5, mitochondrial 

Protein Synonyms/Alias

 Bcl-XL-binding protein v68; Phosphoglycerate mutase family member 5 

Gene Name

 PGAM5 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
88	GEEELASKLDHYKAK	ubiquitination	[1]
141	RLASLGLKFNKIVHS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2- dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore. 

Sequence Annotation

 REGION 77 82 Interaction with KEAP1.
 MOD_RES 80 80 Phosphoserine.
 MOD_RES 116 116 N6-acetyllysine.
 MOD_RES 144 144 N6-acetyllysine.
 MOD_RES 191 191 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Hydrolase; Membrane; Mitochondrion; Mitochondrion outer membrane; Necrosis; Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 289 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
 GO:0004721; F:phosphoprotein phosphatase activity; IEA:EC. 

Interpro

 IPR013078; His_Pase_superF_clade-1. 

Pfam

 PF00300; His_Phos_1 

SMART

 SM00855; PGAM 

PROSITE

 PS00175; PG_MUTASE 

PRINTS