UniProt Accession

 H33_DROME; P84249; A4V466; P06351; P33155; Q9V3W4 

Genbank Protein ID

 X53822; X82257; X81205; X81207; AE014298; AE014134; AE014298; AE014298; AY071057; AY118325; AY119629 

Genbank Nucleotide ID

 CAA37819.1; CAA57712.1; CAA57077.1; CAA57080.1; AAF46452.1; AAF52213.1; AAN09245.1; AAO41645.1; AAL48679.1; AAM48354.1; AAM50283.1 

Protein Name

 Histone H3.3 

Protein Synonyms/Alias

 H3.3Q; H3.A/B 

Gene Name

 His3.3A; His3.3B 

Gene Synonyms/Alias

 CG5825; CG8989 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
37	APSTGGVKKPHRYRP	acetylation	[1]
38	PSTGGVKKPHRYRPG	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes and is specifically enriched in modifications associated with active chromatin. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. 

Sequence Annotation

 MOD_RES 5 5 N6,N6,N6-trimethyllysine; alternate.
 MOD_RES 5 5 N6,N6-dimethyllysine; alternate.
 MOD_RES 5 5 N6-methyllysine; alternate.
 MOD_RES 10 10 N6,N6-dimethyllysine; alternate.
 MOD_RES 10 10 N6-acetyllysine; alternate.
 MOD_RES 10 10 N6-methyllysine; alternate.
 MOD_RES 11 11 Phosphoserine (By similarity).
 MOD_RES 15 15 N6,N6-dimethyllysine; alternate.
 MOD_RES 15 15 N6-acetyllysine; alternate.
 MOD_RES 15 15 N6-methyllysine; alternate.
 MOD_RES 19 19 N6-acetyllysine.
 MOD_RES 24 24 N6-acetyllysine.
 MOD_RES 28 28 N6,N6,N6-trimethyllysine; alternate.
 MOD_RES 28 28 N6,N6-dimethyllysine; alternate.
 MOD_RES 28 28 N6-methyllysine; alternate.
 MOD_RES 37 37 N6,N6-dimethyllysine; alternate.
 MOD_RES 37 37 N6-methyllysine; alternate.
 MOD_RES 38 38 N6,N6-dimethyllysine; alternate.
 MOD_RES 38 38 N6-methyllysine; alternate.
 MOD_RES 80 80 N6,N6-dimethyllysine; alternate.
 MOD_RES 80 80 N6-methyllysine; alternate.  

Keyword

 Acetylation; Chromosome; Complete proteome; DNA-binding; Methylation; Nucleosome core; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 136 AA 

Protein Sequence

Gene Ontology

 GO:0000786; C:nucleosome; NAS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005700; C:polytene chromosome; IDA:FlyBase.
 GO:0003677; F:DNA binding; NAS:UniProtKB.
 GO:0007155; P:cell adhesion; IMP:FlyBase.
 GO:0007140; P:male meiosis; IGI:FlyBase.
 GO:0006334; P:nucleosome assembly; NAS:UniProtKB.
 GO:0008360; P:regulation of cell shape; IMP:FlyBase. 

Interpro

 IPR009072; Histone-fold.
 IPR007125; Histone_core_D.
 IPR000164; Histone_H3. 

Pfam

 PF00125; Histone 

SMART

 SM00428; H3 

PROSITE

 PS00322; HISTONE_H3_1
 PS00959; HISTONE_H3_2 

PRINTS

 PR00622; HISTONEH3.