Tag | Content |
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CPLM ID | CPLM-013351 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Xin actin-binding repeat-containing protein 2 |
Protein Synonyms/Alias | Beta-xin; Cardiomyopathy-associated protein 3; Myogenic MEF2-activated Xin-related protein; Myomaxin; mXinbeta |
Gene Name | Xirp2 |
Gene Synonyms/Alias | Cmya3; Xin2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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825 | EIQAGNVKSARWLFE | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Protects actin filaments from depolymerization (By similarity). |
Sequence Annotation | REPEAT 308 323 Xin 1. REPEAT 343 358 Xin 2. REPEAT 383 398 Xin 3. REPEAT 420 435 Xin 4. REPEAT 458 473 Xin 5. REPEAT 498 513 Xin 6. REPEAT 536 551 Xin 7. REPEAT 574 589 Xin 8. REPEAT 608 623 Xin 9. REPEAT 642 657 Xin 10. REPEAT 679 694 Xin 11. REPEAT 715 730 Xin 12. REPEAT 746 761 Xin 13. REPEAT 784 799 Xin 14. REPEAT 822 837 Xin 15. REPEAT 861 876 Xin 16. REPEAT 894 909 Xin 17. REPEAT 932 947 Xin 18. REPEAT 967 982 Xin 19. REPEAT 1006 1021 Xin 20. REPEAT 1042 1057 Xin 21. REPEAT 1079 1094 Xin 22. REPEAT 1117 1132 Xin 23. REPEAT 1154 1169 Xin 24. REPEAT 1188 1203 Xin 25. REPEAT 1219 1234 Xin 26. REPEAT 1256 1271 Xin 27. REPEAT 1291 1306 Xin 28. DOMAIN 3255 3315 LIM zinc-binding. |
Keyword | Actin-binding; Alternative splicing; Cell junction; Coiled coil; Complete proteome; LIM domain; Metal-binding; Reference proteome; Repeat; Zinc. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 3784 AA |
Protein Sequence | MARYQAAVSR GDTRSFSANV MEESDVCTVP GGLAKMKRQF EKDKMTSTCN AFSEYQYRHE 60 SRAEQEAIHS SQEIIRRNEQ EVSKGHGTDV FKAEMMSHLE KHTEETKQAS QFHQYVQETV 120 IDSPEEEELP KVSTKILKEQ FEKSAQENFL RSDKETSPPA KCMKIENDIE ETLKPSSAVG 180 TSSSYTSTRQ RKETSTSSYS NHSLTSTTLA QDNGTPSGKM EEFPPPPPDV CQTPMDVTAF 240 SQSPEFPSPP RRLPMPKDLY SKQRNLYELN RLYRHIHPEL RKNLEKDYIS EVSEIVSSQI 300 NSGNALSADV QKARYVFENT NDSSQKDLNS ERENLEWDEI LKGEVQSIRW IFENQPLDSI 360 NHGSTDEGYT SKGIADQELI AGSDVKYTTW MFETQPIDAL GIPSAGTEGN TEKIPELARG 420 DVYTARWMFE TRPLDSMNKM HECQEETAST LTKDITGGDV KTVRYMFETQ QLDQLGQLHS 480 VDELNLLQLR SELKEIKGNV KRSIKCFETQ PLYVIRDGSG QMLEIKTVQR EDIEKGDVRT 540 ARWMFETQPL DTINKDITEI KVVRGISMEE NVKGGVSRAK WLFETQPLEK IKEESGEAVL 600 KTEAVIGTDV SKKCWMFETQ PLDILKDSPD TDSVSPEERI GGDVKTTKHL FETLPIEALK 660 DSPDIGKLQK ITASEEEKGD VKHQKWVFET QRLEDIREDK KEYTRTVRLE AVDRGHVKNY 720 THIFESNNLI KVDASHQIEV EGVTRGTVEL NKSLFETTPL YAIQDHLGKY HQVKTVQQEE 780 IVRGDVRSCR WLFETRPIDQ FDESLHKFQI IRGISAQEIQ AGNVKSARWL FETQPLDSIK 840 YFSNVEETDS KTEQSTDIVK GDVKTCKWLF ETQPMESLYE KASLMTNSED IHKGDVRTCM 900 WLFETQPLDA IKDDSEATVK LQTVKQEEIQ GGDVQTACFL FETENLDNIQ GDEGKENKPL 960 EMDIQSGDVS GMKFKFENQS LDSINCSSEN VLSKIKTLKA EDIQKGNVLK CRWLFENQPI 1020 DMIKESQECD GLVKTVTDVQ GGDVRKGCFI FETFSLDEIK DESDGISMRE TNLGEIIKGD 1080 VKSYKMLFET QPLYAIQDHE GFYHEVTTVK KEETIHGDVR GTRWLFETKP LDSIHESEDV 1140 YVIKSVTQED IQKGDVSSVR YRFETQPLDM ISDKSHNIVP TVDYIQGGNV QMNKQLFESE 1200 GGNKKNYVRT VSVNEIQKGN VKTSTWLFET HRIDELGEES RYENIKTVTQ EDVQKGDVKQ 1260 AVWLFENQTL DSINELDEND TKMTKEEIPP SDVKTTTWLF ETTPIHEFNK TRVEKEEIIG 1320 KSIKETLEDL YSQRVVEAPG IIIEADEVGD VRMAKYKLMN QTTPEIQKEE VIRADLGNIM 1380 MNLLSQRDCT KKEIFVSEEE KGNVNFTKTQ LLNRSMEFHA EKEEIVRGDV KQAIQKLFSE 1440 ERRAKKGILI QEDEKGDINM TIYCLLHENA GDKTEREDIL GGDVRRTIHN LLSSASNGKI 1500 SERTKIDASE RGNVQFFTTC IETGALDYLK QLQTGSNEST LTASKQEGEE EIIGGDVEGT 1560 KFLLKKRQSS FERTVSETDI IPGDVRHTVK VFMTEPQSSS YKTVKDEIIK GDLKSTLNSL 1620 NQAMNQKTVA KAEEIVKDDR LAILKSLKES GDRQKEPKQS GGMSRDIGQA IECLERATNT 1680 RTEILKKELI LDDLKTSLRS LKEEQCGFKE VDKQGIVKDV LPGMLGFSER PKIGIHPAAV 1740 QRDKKSLLQP VPGPFEPAIK QQAGPGTLDE TTQKPCLRSL IEERTEANLP KAPKGTVKIV 1800 IDREQNNDAL EKSLRKMSNS EHRAMKNVLD MSDRMGIWTE SKEYLCSDDH MSKHLSATMS 1860 IKESLKSKES ENMREAKDDV ISSTQSVDKT FRKQQTQTCE LGNDQKSRFQ DSYGKNQKNI 1920 QNIEITRDFQ KQALLSQEKQ YSNKEMKKNE ASLQPLPVGK EVHSVPGVTV SGKNHKRIQA 1980 TDKRQKTDVC LESQDFLMKT NTSKELKMAM ERSFNPINLH PECGIKENED SLPPPSPPPL 2040 PPSNASSEIE FPLPPPPPLM LLPGKNESPP SSPTEKTRTE FESLSTLPLP PPPVDEKAEQ 2100 ECLSTTLPPP PPPTPCQPGH LLPSSVLGHH REAFLQQFSQ KEALGVHLPH SQAKILTGKS 2160 PPPTLPKPKL PKRIKDKMNQ YSSSGELERS LSDVEIKATL SKDQKRSMVT MSSEHRETKQ 2220 DVFGKGLVGR KQLPVDSANS LSQTVPEIPA PKEKQTAPLV KSHSFPSGSE QQSPKPYMRK 2280 FKTPLMIAEE KYRQQREELE KQRQESSSHN VIKTETQHQS LSEKEEEIEL QKATEAISTP 2340 RKESDFPRAR PNLDSESRAV IAGECSESQL ATASTLTVAT ERLQHVLAAS EDELTLRQEG 2400 IQNSSDASQS KLACETSQSH KECKAQQTFE QHVKRLPFPQ TKPSSPSFKV KTIKLSTLDH 2460 TGTETDLSSK HHTKQSEVDI QTSTEQTDKE IKKTQASIQC DDKPSVPEKY FQLPKTEKRV 2520 TIQMPKEYAE KSHKSKLQTV PKKQGIFGEF DRGNVLGREG KNQDSSVSCS KEDRLIDERK 2580 QEHLQNQRVP RSVQQKVINE RLDSQMQNFQ QTEIQTSRST IECEEFSQSY NATQEKTCLK 2640 DKGKQQGQVT SNTEESKQEL RQNQSAFSSV KDSQHDDGKC TINILEFLRK REELQQILSR 2700 VKQFEAESSK SGLKTFQILL NIVPVWLISE EKREYGVRVA MENNFEKVKE EITHIKTQAE 2760 EMLLQCEHVI QTAMMASQTG KQRDKPTNLN EMPLNVSNVN LSSSKCTEQK ESKTVEEKLT 2820 HRQVTTHPEA ATRNPVKPYQ EAKGEDGKMA PPSLKTRPPS PTFITIESTA RRAETSTKSE 2880 LSQSPKNNRC IEPPPRRPVE HASGLPRSRT PPSPPRSRSE QLVRLKDTTA RLAKGTIPCS 2940 PGTPVPIVEK RSEVVMSPAT LRRQIKIESR GGDSPPTITI PVSVNHVVSG SFRESVDAQE 3000 AVKKTEKTET YVHKDKMNSV NRAMPETESY DAVEIIRKVE GPHLSEHTER FEATNQTVQR 3060 AERFLNGHEN EINRWFREFE NDPVFRAKTE RGAYANGEIN HNMKQESHTF CKEEFGLASS 3120 ETANFTGFSY RHPKVPAMQP RVHSEARSLN EHFSSVDAFD SQIVGSKVAT SSSRSTEAGR 3180 SGFDFKHAPP TYEDVISGHI LDVADSPTNL RRNFQKTWQE SERVFQRVGY ETSDAHATEM 3240 SRAFQEESAF LSDKEICIIC QKTVYPMECL IADKQNFHKS CFRCHHCSSK LSLGNYASLH 3300 GRIYCKPHFK QLFKSKGNYD EGFGHKQHKD RWNCKNQSSL VDFIPSGEPD AHENPTADTL 3360 LLGDLTTHPD ACNSKRQDND LRKWGDRGKL KIVWPPCQEM PKKNSPPEEE FKVNKAKWPP 3420 EVTIPVPSDF KRESLTEHVK TLESQGQEQD SVPDLQPCKH VCQKEDITGI KEIKGYEERK 3480 DEKEAKDTLK DAEGLRSKRK SGMEFNDHNA HAQSDGKEKN ALVNEADSAD VLQVANTDDE 3540 GGPENHRENF NNNNNNSVAV SSLNNGRQKI SISERPRLLQ AVSEANYYTS EYQIKNFNNA 3600 SKISELLGIF ESQKLSSKKV LALALERTAD RGTAGSPLQL VLEPGLQQGF SVKGENLAAS 3660 PDVSPLHIKG NHENNKNVHL FFSNTVKITS FSKKHNILGC DLMDSVDQLK NMSCLYLREL 3720 GKNVKCWHGE TAGAARHGGK MCFDAQSQGS AAKPVFPSMQ CQAQHLTVEE QIKRDRCYSD 3780 SEAD 3784 |
Gene Ontology | GO:0030054; C:cell junction; IEA:UniProtKB-SubCell. GO:0030018; C:Z disc; IDA:MGI. GO:0051393; F:alpha-actinin binding; IDA:MGI. GO:0008270; F:zinc ion binding; IEA:InterPro. GO:0030036; P:actin cytoskeleton organization; IEA:InterPro. GO:0055008; P:cardiac muscle tissue morphogenesis; IMP:MGI. GO:0045216; P:cell-cell junction organization; IMP:MGI. GO:0003281; P:ventricular septum development; IMP:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |