UniProt Accession

 BACD2_MOUSE; O70479; Q3TH85; Q3UGQ5; Q8BV61; Q8BZK5 

Genbank Protein ID

 AF061346; AF061341; AF061342; AF061343; AF061344; AF061345; AK004593; AK034305; AK079869; AK147809; AK168386; AK168704; AL591177; BC003906 

Genbank Nucleotide ID

 AAC78826.1; AAC78826.1; AAC78826.1; AAC78826.1; AAC78826.1; AAC78826.1; BAB23395.1; BAC28668.1; BAC37770.1; BAE28152.1; BAE40313.1; BAE40546.1; CAI25552.1; AAH03906.1 

Protein Name

 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 

Protein Synonyms/Alias

 BTB/POZ domain-containing protein TNFAIP1; Tumor necrosis factor, alpha-induced protein 1, endothelial 

Gene Name

 Tnfaip1 

Gene Synonyms/Alias

 Edp1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	KPKISGFKGGGLGNK	ubiquitination	[1]
168	LYNRSNNKYSYTSNS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity). 

Sequence Annotation

 DOMAIN 28 96 BTB.
 MOD_RES 278 278 Phosphoserine (By similarity).
 MOD_RES 280 280 Phosphoserine; by CK2.  

Keyword

 Complete proteome; Cytoplasm; Endosome; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 316 AA 

Protein Sequence

Gene Ontology

 GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.
 GO:0005768; C:endosome; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0017049; F:GTP-Rho binding; ISS:UniProtKB.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara.
 GO:0016477; P:cell migration; ISS:UniProtKB.
 GO:0006260; P:DNA replication; ISS:UniProtKB.
 GO:0009790; P:embryo development; IEP:UniProtKB.
 GO:0006955; P:immune response; ISS:UniProtKB.
 GO:0035024; P:negative regulation of Rho protein signal transduction; ISS:UniProtKB.
 GO:0045740; P:positive regulation of DNA replication; IEA:Compara.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
 GO:0043149; P:stress fiber assembly; ISS:UniProtKB. 

Interpro

 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR003131; T1-type_BTB. 

Pfam

 PF02214; K_tetra 

SMART

 SM00225; BTB 

PROSITE

 PS50097; BTB 

PRINTS