CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007142
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alcohol dehydrogenase, propanol-preferring 
Protein Synonyms/Alias
  
Gene Name
 adhP 
Gene Synonyms/Alias
 yddN; b1478; JW1474 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
225AAKIVQEKTGGAHAAacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Preferred specificity is towards 1-propanol. 
Sequence Annotation
 METAL 37 37 Zinc 1; catalytic (By similarity).
 METAL 58 58 Zinc 1; catalytic (By similarity).
 METAL 89 89 Zinc 2 (By similarity).
 METAL 92 92 Zinc 2 (By similarity).
 METAL 95 95 Zinc 2 (By similarity).
 METAL 103 103 Zinc 2 (By similarity).
 METAL 145 145 Zinc 1; catalytic (By similarity).  
Keyword
 Complete proteome; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 336 AA 
Protein Sequence
MKAAVVTKDH HVDVTYKTLR SLKHGEALLK MECCGVCHTD LHVKNGDFGD KTGVILGHEG 60
IGVVAEVGPG VTSLKPGDRA SVAWFYEGCG HCEYCNSGNE TLCRSVKNAG YSVDGGMAEE 120
CIVVADYAVK VPDGLDSAAA SSITCAGVTT YKAVKLSKIR PGQWIAIYGL GGLGNLALQY 180
AKNVFNAKVI AIDVNDEQLK LATEMGADLA INSHTEDAAK IVQEKTGGAH AAVVTAVAKA 240
AFNSAVDAVR AGGRVVAVGL PPESMSLDIP RLVLDGIEVV GSLVGTRQDL TEAFQFAAEG 300
KVVPKVALRP LADINTIFTE MEEGKIRGRM VIDFRH 336 
Gene Ontology
 GO:0004022; F:alcohol dehydrogenase (NAD) activity; IDA:EcoCyc.
 GO:0047639; F:alcohol oxidase activity; IDA:EcoliWiki.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0046187; P:acetaldehyde catabolic process; IDA:EcoliWiki.
 GO:0006974; P:response to DNA damage stimulus; IEP:EcoliWiki.
 GO:0045471; P:response to ethanol; IEP:EcoliWiki. 
Interpro
 IPR013149; ADH_C.
 IPR013154; ADH_GroES-like.
 IPR002085; ADH_SF_Zn-type.
 IPR002328; ADH_Zn_CS.
 IPR011032; GroES-like.
 IPR016040; NAD(P)-bd_dom. 
Pfam
 PF08240; ADH_N
 PF00107; ADH_zinc_N 
SMART
  
PROSITE
 PS00059; ADH_ZINC 
PRINTS