| Tag | Content |
|---|
| CPLM ID | CPLM-023349 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sphingosine-1-phosphate lyase |
Protein Synonyms/Alias | S1PL; SP-lyase; SPL; Sphingosine-1-phosphate aldolase |
Gene Name | Sply |
Gene Synonyms/Alias | Spl; CG8946 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 342 | SISADTHKYGFAPKG | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Sphingolipid catabolism is required for normal development including viability, reproduction and muscle development. |
Sequence Annotation | MOD_RES 342 342 N6-(pyridoxal phosphate)lysine (By |
Keyword | Complete proteome; Developmental protein; Endoplasmic reticulum; Lipid metabolism; Lyase; Membrane; Pyridoxal phosphate; Reference proteome; Signal-anchor; Sphingolipid metabolism; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 545 AA |
Protein Sequence | MRPFSGSDCL KPVTEGINRA FGAKEPWQVA TITATTVLGG VWLWTVICQD ENLYIRGKRQ 60
FFKFAKKIPA VRRQVETELA KAKNDFETEI KKSNAHLTYS ETLPEKGLSK EEILRLVDEH 120
LKTGHYNWRD GRVSGAVYGY KPDLVELVTE VYGKASYTNP LHADLFPGVC KMEAEVVRMA 180
CNLFHGNSAS CGTMTTGGTE SIVMAMKAYR DFAREYKGIT RPNIVVPKTV HAAFDKGGQY 240
FNIHVRSVDV DPETYEVDIK KFKRAINRNT ILLVGSAPNF PYGTIDDIEA IAALGVKYDI 300
PVHVDACLGS FVVALVRNAG YKLRPFDFEV KGVTSISADT HKYGFAPKGS SVILYSDKKY 360
KDHQFTVTTD WPGGVYGSPT VNGSRAGGII AACWATMMSF GYDGYLEATK RIVDTARYIE 420
RGVRDIDGIF IFGKPATSVI ALGSNVFDIF RLSDSLCKLG WNLNALQFPS GIHLCVTDMH 480
TQPGVADKFI ADVRSCTAEI MKDPGQPVVG KMALYGMAQS IPDRSVIGEV TRLFLHSMYY 540
TPSQK 545 |
Gene Ontology | GO:0030176; C:integral to endoplasmic reticulum membrane; NAS:UniProtKB. GO:0016831; F:carboxy-lyase activity; IEA:InterPro. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0008117; F:sphinganine-1-phosphate aldolase activity; NAS:UniProtKB. GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro. GO:0046331; P:lateral inhibition; IMP:FlyBase. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0030149; P:sphingolipid catabolic process; NAS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |