CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039905
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Probable ATP-dependent RNA helicase DHX37 
Protein Synonyms/Alias
  
Gene Name
 DHX37 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
19PLPRALAKPAVFIPVubiquitination[1]
212QNPRLFAKPPPVIKVubiquitination[1]
427KYVVDCGKVKKRYYDubiquitination[1]
500EDLILQMKALNVEKVubiquitination[2]
544PQKAERVKQLQENRLubiquitination[1]
573PVAPRYAKMLALSRQubiquitination[1]
737SEEMLEDKWRNAYKTubiquitination[1]
743DKWRNAYKTPLLDDPubiquitination[1]
880SSPGTMLKTWARLQPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 962 AA 
Protein Sequence
MTVPPPPAAA PPLPRALAKP AVFIPVNRSP EMQEERLKLP ILSEEQVIME AVAEHPIVIV 60
CGETGSGKTT QVPQFLYEAG FSSEDSIIGV TEPRRVAAVA MSQRVAKEMN LSQRVVSYQI 120
RYEGNVTEET RIKFMTDGVL LKEIQKDFLL LRYKVVIIDE AHERSVYTDI LIGLLSRIVT 180
LRAKRNLPLK LLIMSATLRV EDFTQNPRLF AKPPPVIKVE SRQFPVTVHF NKRTPLEDYS 240
GECFRKVCKI HRMLPAGGIL VFLTGQAEVH ALCRRLRKAF PPSRARPQEK DDDQKDSVEE 300
MRKFKKSRAR AKKARAEVLP QINLDHYSVL PAGEGDEDRE AEVDEEEGAL DSDLDLDLGD 360
GGQDGGEQPD ASLPLHVLPL YSLLAPEKQA QVFKPPPEGT RLCVVATNVA ETSLTIPGIK 420
YVVDCGKVKK RYYDRVTGVS SFRVTWVSQA SADQRAGRAG RTEPGHCYRL YSSAVFGDFE 480
QFPPPEITRR PVEDLILQMK ALNVEKVINF PFPTPPSVEA LLAAEELLIA LGALQPPQKA 540
ERVKQLQENR LSCPITALGR TMATFPVAPR YAKMLALSRQ HGCLPYAITI VASMTVRELF 600
EELDRPAASD EELTRLKSKR ARVAQMKRTW AGQGASLKLG DLMVLLGAVG ACEYASCTPQ 660
FCEANGLRYK AMMEIRRLRG QLTTAVNAVC PEAELFVDPK MQPPTESQVT YLRQIVTAGL 720
GDHLARRVQS EEMLEDKWRN AYKTPLLDDP VFIHPSSVLF KELPEFVVYQ EIVETTKMYM 780
KGVSSVEVQW IPALLPSYCQ FDKPLEEPAP TYCPERGRVL CHRASVFYRV GWPLPAIEVD 840
FPEGIDRYKH FARFLLEGQV FRKLASYRSC LLSSPGTMLK TWARLQPRTE SLLRALVAEK 900
ADCHEALLAA WKKNPKCEFD QGQGVGVDRM GSLRQGLCAL CTVSPGLAEG SGPTAAGQLF 960
AT 962 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR011709; DUF1605.
 IPR007502; Helicase-assoc_dom.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00270; DEAD
 PF04408; HA2
 PF00271; Helicase_C
 PF07717; OB_NTP_bind 
SMART
 SM00487; DEXDc
 SM00847; HA2
 SM00490; HELICc 
PROSITE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER 
PRINTS