UniProt Accession

 GPX7_MOUSE; Q99LJ6 

Genbank Protein ID

 BC003228 

Genbank Nucleotide ID

 AAH03228.1 

Protein Name

 Glutathione peroxidase 7 

Protein Synonyms/Alias

 GPx-7; GSHPx-7 

Gene Name

 Gpx7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
41	GKLVSLEKYRGSVSL	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity). 

Sequence Annotation

 ACT_SITE 56 56 By similarity.  

Keyword

 Complete proteome; Oxidoreductase; Peroxidase; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 186 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0004602; F:glutathione peroxidase activity; IEA:EC.
 GO:0006979; P:response to oxidative stress; IEA:InterPro. 

Interpro

 IPR013376; Glut_perox_Gpx7.
 IPR000889; Glutathione_peroxidase.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00255; GSHPx 

SMART

  

PROSITE

 PS00460; GLUTATHIONE_PEROXID_1
 PS00763; GLUTATHIONE_PEROXID_2
 PS51355; GLUTATHIONE_PEROXID_3 

PRINTS

 PR01011; GLUTPROXDASE.