| Tag | Content |
|---|
| CPLM ID | CPLM-019792 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Amyloid beta A4 precursor protein-binding family A member 2 |
Protein Synonyms/Alias | Adapter protein X11beta; Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2; Mint-2 |
Gene Name | APBA2 |
Gene Synonyms/Alias | MINT2; X11L |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 347 | NNIPETKKVASFPSF | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. |
Sequence Annotation | DOMAIN 368 555 PID.
DOMAIN 568 654 PDZ 1.
DOMAIN 659 734 PDZ 2.
REGION 185 270 STXBP1-binding.
MOD_RES 208 208 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Repeat; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 749 AA |
Protein Sequence | MAHRKLESVG SGMLDHRVRP GPVPHSQEPE SEDMELPLEG YVPEGLELAA LRPESPAPEE 60
QECHNHSPDG DSSSDYVNNT SEEEDYDEGL PEEEEGITYY IRYCPEDDSY LEGMDCNGEE 120
YLAHSAHPVD TDECQEAVEE WTDSAGPHPH GHEAEGSQDY PDGQLPIPED EPSVLEAHDQ 180
EEDGHYCASK EGYQDYYPEE ANGNTGASPY RLRRGDGDLE DQEEDIDQIV AEIKMSLSMT 240
SITSASEASP EHGPEPGPED SVEACPPIKA SCSPSRHEAR PKSLNLLPEA KHPGDPQRGF 300
KPKTRTPEER LKWPHEQVCN GLEQPRKQQR SDLNGPVDNN NIPETKKVAS FPSFVAVPGP 360
CEPEDLIDGI IFAANYLGST QLLSERNPSK NIRMMQAQEA VSRVKRMQKA AKIKKKANSE 420
GDAQTLTEVD LFISTQRIKV LNADTQETMM DHALRTISYI ADIGNIVVLM ARRRMPRSAS 480
QDCIETTPGA QEGKKQYKMI CHVFESEDAQ LIAQSIGQAF SVAYQEFLRA NGINPEDLSQ 540
KEYSDIINTQ EMYNDDLIHF SNSENCKELQ LEKHKGEILG VVVVESGWGS ILPTVILANM 600
MNGGPAARSG KLSIGDQIMS INGTSLVGLP LATCQGIIKG LKNQTQVKLN IVSCPPVTTV 660
LIKRPDLKYQ LGFSVQNGII CSLMRGGIAE RGGVRVGHRI IEINGQSVVA TAHEKIVQAL 720
SNSVGEIHMK TMPAAMFRLL TGQETPLYI 749 |
Gene Ontology | GO:0005886; C:plasma membrane; IEA:Compara. GO:0001540; F:beta-amyloid binding; IEA:Compara. GO:0001701; P:in utero embryonic development; IEA:Compara. GO:0007626; P:locomotory behavior; IEA:Compara. GO:0035264; P:multicellular organism growth; IEA:Compara. GO:0007399; P:nervous system development; TAS:ProtInc. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0010468; P:regulation of gene expression; IEA:Compara. GO:0007268; P:synaptic transmission; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |