UniProt Accession

 SIRPG_HUMAN; Q9P1W8; B1AKP6; Q5D051; Q5JV25; Q5MKL4; Q8WWA5; Q9NQK8 

Genbank Protein ID

 AB042624; AY748247; AY748248; AL109809; AL138804; AL109809; AL138804; AL109809; AL138804; CH471133; BC020629; BC064532 

Genbank Nucleotide ID

 BAA95692.1; AAV88530.1; AAV88531.1; CAM28283.1; CAM28283.1; CAM28284.1; CAM28284.1; CAM28285.1; CAM28285.1; EAX10616.1; AAH20629.2; AAH64532.1 

Protein Name

 Signal-regulatory protein gamma 

Protein Synonyms/Alias

 SIRP-gamma; CD172 antigen-like family member B; Signal-regulatory protein beta-2; SIRP-b2; SIRP-beta-2; CD172g 

Gene Name

 SIRPG 

Gene Synonyms/Alias

 SIRPB2 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
96	TTVSDLTKRNNMDFS	ubiquitination	[1]
121	VGTYYCVKFRKGSPE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. 

Sequence Annotation

 DOMAIN 29 137 Ig-like V-type.
 DOMAIN 146 245 Ig-like C1-type 1.
 DOMAIN 252 340 Ig-like C1-type 2.
 CARBOHYD 243 243 N-linked (GlcNAc...).
 CARBOHYD 268 268 N-linked (GlcNAc...) (Potential).
 CARBOHYD 309 309 N-linked (GlcNAc...) (Potential).
 CARBOHYD 317 317 N-linked (GlcNAc...) (Potential).
 DISULFID 53 119
 DISULFID 168 226 Potential.
 DISULFID 271 329 Potential.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 387 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
 GO:0007267; P:cell-cell signaling; TAS:ProtInc.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.
 GO:0008284; P:positive regulation of cell proliferation; IDA:UniProtKB.
 GO:0022409; P:positive regulation of cell-cell adhesion; IDA:UniProtKB.
 GO:0050870; P:positive regulation of T cell activation; IDA:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003597; Ig_C1-set.
 IPR003599; Ig_sub.
 IPR013106; Ig_V-set. 

Pfam

 PF07654; C1-set
 PF07686; V-set 

SMART

 SM00409; IG
 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS