UniProt Accession

 HBB_HUMAN; P68871; A4GX73; B2ZUE0; P02023; Q13852; Q14481; Q14510; Q45KT0; Q549N7; Q6FI08; Q6R7N2; Q8IZI1; Q9BX96; Q9UCD6; Q9UCP8; Q9UCP9 

Genbank Protein ID

 M25079; V00499; DQ126270; DQ126271; DQ126272; DQ126273; DQ126274; DQ126275; DQ126276; DQ126277; DQ126278; DQ126279; DQ126280; DQ126281; DQ126282; DQ126283; DQ126284; DQ126285; DQ126286; DQ126287; DQ126288; DQ126289; DQ126290; DQ126291; DQ126292; DQ126293; DQ126294; DQ126295; DQ126296; DQ126297; DQ126298; DQ126299; DQ126300; DQ126301; DQ126302; DQ126303; DQ126304; DQ126305; DQ126306; DQ126307; DQ126308; DQ126309; DQ126310; DQ126311; DQ126312; DQ126313; DQ126314; DQ126315; DQ126316; DQ126317; DQ126318; DQ126319; DQ126320; DQ126321; DQ126322; DQ126323; DQ126324; DQ126325; AF007546; AF083883; AF117710; AF181989; AF349114; AF527577; AY136510; AY163866; AY260740; AY509193; EF450778; EU694432; AK311825; CR536530; CR541913; CH471064; BC007075; U01317; V00497; V00500; L26462; L26463; L26464; L26465; L26466; L26467; L26468; L26469; L26470; L26471; L26472; L26473; L26474; L26475; L26476; L26477; L26478; L48213; L48214; L48215; L48216; L48217; M36640; M11428; M25113; L48932 

Genbank Nucleotide ID

 AAA35597.1; CAA23758.1; AAZ39745.1; AAZ39746.1; AAZ39747.1; AAZ39748.1; AAZ39749.1; AAZ39750.1; AAZ39751.1; AAZ39752.1; AAZ39753.1; AAZ39754.1; AAZ39755.1; AAZ39756.1; AAZ39757.1; AAZ39758.1; AAZ39759.1; AAZ39760.1; AAZ39761.1; AAZ39762.1; AAZ39763.1; AAZ39764.1; AAZ39765.1; AAZ39766.1; AAZ39767.1; AAZ39768.1; AAZ39769.1; AAZ39770.1; AAZ39771.1; AAZ39772.1; AAZ39773.1; AAZ39774.1; AAZ39775.1; AAZ39776.1; AAZ39777.1; AAZ39778.1; AAZ39779.1; AAZ39780.1; AAZ39781.1; AAZ39782.1; AAZ39783.1; AAZ39784.1; AAZ39785.1; AAZ39786.1; AAZ39787.1; AAZ39788.1; AAZ39789.1; AAZ39790.1; AAZ39791.1; AAZ39792.1; AAZ39793.1; AAZ39794.1; AAZ39795.1; AAZ39796.1; AAZ39797.1; AAZ39798.1; AAZ39799.1; AAZ39800.1; AAB62944.1; AAL68978.1; AAD19696.1; AAF00489.1; AAK29639.1; AAM92001.1; AAN11320.1; AAN84548.1; AAP21062.1; AAR96398.1; ABO36678.1; ACD39349.1; BAG34767.1; CAG38767.1; CAG46711.1; EAW68806.1; AAH07075.1; AAA16334.1; CAA23756.1; CAA23759.1; AAA21100.1; AAA21101.1; AAA21102.1; AAA21103.1; AAA21104.1; AAA21105.1; AAA21106.1; AAA21107.1; AAA21108.1; AAA21109.1; AAA21110.1; AAA21111.1; AAA21112.1; AAA21113.1; AAA21114.1; AAA21115.1; AAA21116.1; AAA88063.1; AAA88061.1; AAA88059.1; AAA88065.1; AAA88067.1; AAA52634.1; AAA52633.1; AAA35966.1; AAA88054.1 

Protein Name

 Hemoglobin subunit beta 

Protein Synonyms/Alias

 Beta-globin; Hemoglobin beta chain; LVV-hemorphin-7 

Gene Name

 HBB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	VHLTPEEKSAVTALW	glycation	[1]
18	AVTALWGKVNVDEVG	acetylation	[2]
18	AVTALWGKVNVDEVG	glycation	[1]
67	KVKAHGKKVLGAFSD	glycation	[1]
83	LAHLDNLKGTFATLS	acetylation	[3, 4, 5, 6]
121	VLAHHFGKEFTPPVQ	glycation	[1]
145	VANALAHKYH*****	acetylation	[3, 4, 5]
145	VANALAHKYH*****	glycation	[1]

Reference

 [1] Sites of nonenzymatic glycosylation of human hemoglobin A.
 Shapiro R, McManus MJ, Zalut C, Bunn HF.
 J Biol Chem. 1980 Apr 10;255(7):3120-7. [PMID: 7358733]
 [2] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [3] Methyl acetyl phosphate, a new type of antisickling agent: site-specific acetylating agent toward the 2,3-DPG binding site in hemoglobin S.
 Ueno H, Manning JM.
 Am J Pediatr Hematol Oncol. 1988 Winter;10(4):348-50. [PMID: 3239714]
 [4] Effects of methyl acetyl phosphate on hemoglobin S: a novel acetylating agent directed towards the DPG binding site.
 Ueno H, Benjamin LJ, Manning JM.
 Prog Clin Biol Res. 1987;240:105-10. [PMID: 3615481]
 [5] Site-specific modification of hemoglobin by methyl acetyl phosphate.
 Ueno H, Pospischil MA, Manning JM, Kluger R.
 Arch Biochem Biophys. 1986 Feb 1;244(2):795-800. [PMID: 3947090]
 [6] Some properties of the reaction site for the esterase activity of hemoglobin.
 Elbaum D, Wiedenmann B, Nagel RL.
 J Biol Chem. 1982 Jul 25;257(14):8454-8. [PMID: 6806298] 

Functional Description

 Involved in oxygen transport from the lung to the various peripheral tissues. 

Sequence Annotation

 METAL 64 64 Iron (heme distal ligand).
 METAL 93 93 Iron (heme proximal ligand).
 BINDING 2 2 2,3-bisphosphoglycerate; via amino
 BINDING 3 3 2,3-bisphosphoglycerate.
 BINDING 83 83 2,3-bisphosphoglycerate.
 BINDING 144 144 2,3-bisphosphoglycerate.
 MOD_RES 2 2 N-acetylalanine; in variant Raleigh.
 MOD_RES 2 2 N-acetylvaline (By similarity).
 MOD_RES 2 2 N-pyruvate 2-iminyl-valine; in Hb A1b.
 MOD_RES 94 94 S-nitrosocysteine.
 CARBOHYD 2 2 N-linked (Glc) (glycation); in Hb A1c.
 CARBOHYD 9 9 N-linked (Glc) (glycation).
 CARBOHYD 18 18 N-linked (Glc) (glycation).
 CARBOHYD 67 67 N-linked (Glc) (glycation).
 CARBOHYD 121 121 N-linked (Glc) (glycation).
 CARBOHYD 145 145 N-linked (Glc) (glycation).  

Keyword

 3D-structure; Acetylation; Complete proteome; Congenital dyserythropoietic anemia; Direct protein sequencing; Disease mutation; Glycation; Glycoprotein; Heme; Hereditary hemolytic anemia; Hypotensive agent; Iron; Metal-binding; Oxygen transport; Polymorphism; Pyruvate; Reference proteome; S-nitrosylation; Transport; Vasoactive. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0071682; C:endocytic vesicle lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0031838; C:haptoglobin-hemoglobin complex; IDA:BHF-UCL.
 GO:0005833; C:hemoglobin complex; NAS:UniProtKB.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0030492; F:hemoglobin binding; IDA:UniProtKB.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0019825; F:oxygen binding; IDA:UniProtKB.
 GO:0005344; F:oxygen transporter activity; NAS:UniProtKB.
 GO:0015701; P:bicarbonate transport; TAS:Reactome.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0042744; P:hydrogen peroxide catabolic process; IDA:BHF-UCL.
 GO:0030185; P:nitric oxide transport; NAS:UniProtKB.
 GO:0010942; P:positive regulation of cell death; IDA:BHF-UCL.
 GO:0045429; P:positive regulation of nitric oxide biosynthetic process; NAS:UniProtKB.
 GO:0051291; P:protein heterooligomerization; IDA:BHF-UCL.
 GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
 GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW.
 GO:0070293; P:renal absorption; IMP:UniProtKB.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR000971; Globin.
 IPR009050; Globin-like.
 IPR012292; Globin_dom.
 IPR002337; Haemoglobin_b. 

Pfam

 PF00042; Globin 

SMART

  

PROSITE

 PS01033; GLOBIN 

PRINTS

 PR00814; BETAHAEM.