| Tag | Content |
|---|
| CPLM ID | CPLM-013072 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Heparan-alpha-glucosaminide N-acetyltransferase |
Protein Synonyms/Alias | Transmembrane protein 76 |
Gene Name | Hgsnat |
Gene Synonyms/Alias | D8Ertd354e; Tmem76 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 67 | AEPDLDEKRNVELKM | acetylation | [1] |
|
Reference | [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [ PMID: 23576753] |
Functional Description | Lysosomal acetyltransferase that acetylates the non- reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase. |
Sequence Annotation | REGION 641 656 Lysosomal targeting region (By
ACT_SITE 290 290 By similarity.
MOD_RES 234 234 Phosphoserine.
MOD_RES 240 240 Phosphoserine (By similarity).
MOD_RES 249 249 Phosphotyrosine.
CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
CARBOHYD 157 157 N-linked (GlcNAc...).
DISULFID 146 455 By similarity. |
Keyword | Acyltransferase; Alternative initiation; Complete proteome; Disulfide bond; Glycoprotein; Lysosome; Membrane; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 656 AA |
Protein Sequence | MTGGSSSRRR RAEERSSAAG TERNSRREAV GGMGAGPALA ALLLAGSVLS ATLLAPGRRA 60
EPDLDEKRNV ELKMDQALLL IHNELLGTSL TVYWKSDDCY QCTFQPLANV SHGGKPAKPS 120
VAPVSVSTQH GSILQVNSTS EERAACRLEY KFGEFGNYSL LVQHASSGAN KIACDIIVNE 180
NPVDSNLPVS IAFLVGLALI VAVSLLRLLL SLDDVNNWIS KTIASRETDR LINSELGSPS 240
RADPLSADYQ PETRRSSANR LRCVDTFRGL ALVLMVFVNY GGGKYWYFKH SSWNGLTVAD 300
LVFPWFVFIM GTSIFLSMTS ILQRGCSKLK LLGKIVWRSF LLICIGVIIV NPNYCLGPLS 360
WDKVRIPGVL QRLGVTYFVV AVLEFFFWKP VPDSCTLESS CFSLRDITSS WPQWLTILTL 420
ESIWLALTFF LPVPGCPTGY LGPGGIGDLG KYPHCTGGAA GYIDRLLLGD NHLYQHPSST 480
VLYHTEVAYD PEGVLGTINS IVMAFLGVQA GKILVYYKDQ TKAILTRFAA WCCILGLISI 540
VLTKVSANEG FIPINKNLWS ISYVTTLSCF AFFILLILYP VVDVKGLWTG TPFFYPGMNS 600
ILVYVGHEVL ENYFPFQWKL ADEQSHKEHL IQNIVATALW VLIAYVLYKK KLFWKI 656 |
Gene Ontology | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0005765; C:lysosomal membrane; ISS:UniProtKB. GO:0015019; F:heparan-alpha-glucosaminide N-acetyltransferase activity; IEA:EC. GO:0016746; F:transferase activity, transferring acyl groups; ISS:UniProtKB. GO:0007041; P:lysosomal transport; ISS:UniProtKB. GO:0051259; P:protein oligomerization; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |