UniProt Accession

 TTHY_RAT; P02767; Q547K9 

Genbank Protein ID

 K03252; K03251; X14876; AF479660; BC086946; M18685; M20246 

Genbank Nucleotide ID

 AAA41801.1; AAA41802.1; CAA33017.1; AAL78377.1; AAH86946.1; AAA40708.1; AAA40709.1 

Protein Name

 Transthyretin 

Protein Synonyms/Alias

 Prealbumin; TBPA 

Gene Name

 Ttr 

Gene Synonyms/Alias

 Tt 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
35	SKCPLMVKVLDAVRG	acetylation	[1]
54	DVAVKVFKKTADGSW	acetylation	[1]
55	VAVKVFKKTADGSWE	acetylation	[1]
68	WEPFASGKTAESGEL	acetylation	[1]
83	HGLTTDEKFTEGVYR	acetylation	[1]
96	YRVELDTKSYWKALG	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. 

Sequence Annotation

 REGION 135 139 Thyroid hormone binding.
 BINDING 35 35 Thyroid hormone.
 BINDING 74 74 Thyroid hormone.
 MOD_RES 62 62 4-carboxyglutamate (By similarity).
 CARBOHYD 118 118 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Gamma-carboxyglutamic acid; Glycoprotein; Hormone; Reference proteome; Secreted; Signal; Thyroid hormone; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 147 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0042562; F:hormone binding; IDA:RGD.
 GO:0046982; F:protein heterodimerization activity; IDA:RGD.
 GO:0042572; P:retinol metabolic process; IDA:RGD.
 GO:0042403; P:thyroid hormone metabolic process; TAS:RGD.
 GO:0006810; P:transport; IEA:UniProtKB-KW. 

Interpro

 IPR023418; Thyroxine_BS.
 IPR000895; Transthyretin/HIU_hydrolase.
 IPR023416; Transthyretin/HIU_hydrolase_SF.
 IPR023419; Transthyretin_CS. 

Pfam

 PF00576; Transthyretin 

SMART

 SM00095; TR_THY 

PROSITE

 PS00768; TRANSTHYRETIN_1
 PS00769; TRANSTHYRETIN_2 

PRINTS

 PR00189; TRNSTHYRETIN.