| Tag | Content |
|---|
| CPLM ID | CPLM-016862 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein unc-45 homolog B |
Protein Synonyms/Alias | Unc-45B |
Gene Name | Unc45b |
Gene Synonyms/Alias | Cmya4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 39 | ALKLTKDKALLATLY | ubiquitination | [1] | | 600 | PELVQLAKFSKQHVP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a co-chaperone for HSP90 and is required for proper folding of the myosin motor domain. Plays a role in sarcomere formation during muscle cell development. |
Sequence Annotation | REPEAT 6 39 TPR 1.
REPEAT 43 76 TPR 2.
REPEAT 77 110 TPR 3.
REPEAT 169 208 ARM 1.
REPEAT 211 250 ARM 2.
REPEAT 751 790 ARM 3. |
Keyword | Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Myogenesis; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 931 AA |
Protein Sequence | MAEAEAAQLK EEGNRHFQLQ DYKAATKSYS QALKLTKDKA LLATLYRNRA ACGLKMESYA 60
QAASDASRAI DINSADIKAL YRRCQALEHL GKLDQAFKDV QRCATLEPRN QNFQETLRRL 120
NTSIQEQLRV QFSTDSRVQT MFEILLNENS EADKREKAAN NLIVLGREEA GAERIFQSNG 180
VALLLQLMNT QRPELLLAAV RTLSGMCSGH RARATAILHA VRIDRICSLM ALENEEMSLA 240
VCNLLQAIID SLSGEDKREH RGKEEALVLD TKKDLKQITS HLLDMLVSKK VSGQGRDQAL 300
NLLNKNVPRK DLSIHDNSRT IYVVDNGLRK ILKVVGQVPD LPSCLPLTDN TRMLASILIN 360
KLYDDLRCDP ERDHFRKICE EYITSKFDPQ DMDKNVNAIQ TVSGILQGPF DLGNQLLGMK 420
GVMEMMVALC GSEREADQLV AVEALIHAST KLSRATFIIT NGVTLLKQIY KTTKNEKIKI 480
RTLVGLCKLG SAGGSDYGLR QFAEGSTEKL AKQCRKWLCN TAIDTRTRRW AVEGLAYLTL 540
DADVKDDFVQ DIPALQAMFE LAKARTSDKT ILYSVANTLV NCTNSYDVKE VVPELVQLAK 600
FSKQHVPEEH PKDKKDFVDL RVKRLLKAGV ISALACMVKA DSAILTDQTK ELLARVFLAL 660
CDNPKDRGTI VAQGGGKALI PLALEGTDVG KVKAAHGLAK IAAVSNPDIA FPGERVYEVV 720
RPLVSLLDTQ RDGLQNYEAL LGLTNLSGRS DKLRQKIFKE KALPDIENYM FENHDQLRQA 780
ATECMCNMVL NKEVQERFLA DGNDRLKLVV LLCGEDDHKL QNAAAGALAM LTAAHKKLCL 840
KMTEVTTQWL EILQRLCLHD QLSVQHRGLV IAHNLLSADA ELARKLVESE LLEILTVVGK 900
QEPDEKRAAV VQTARECLIK CMDYGFIKPV S 931 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |