CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038211
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Plectin 
Protein Synonyms/Alias
  
Gene Name
 Plec 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
768LQDAQDEKEQLNEYKacetylation[1]
792AKAIVQLKPRNPAHPacetylation[1]
1025QRIAEQQKAQAEVEGacetylation[1]
1025QRIAEQQKAQAEVEGsuccinylation[1]
1025QRIAEQQKAQAEVEGubiquitination[2]
1035AEVEGLGKGVARLSAubiquitination[2]
1046RLSAEAEKVLALPEPacetylation[3]
1046RLSAEAEKVLALPEPubiquitination[2]
1070ELELTLGKLEQVRSLubiquitination[2]
1084LSAIYLEKLKTISLVacetylation[4]
1261EIERHGEKVEECQKFacetylation[5]
1267EKVEECQKFAKQYINacetylation[1]
1270EECQKFAKQYINAIKacetylation[4]
1368EVEAALEKQRQLAEAubiquitination[2]
1433SEAEIQAKAQQVEAAubiquitination[2]
1578AEVELQSKRASFAEKubiquitination[2]
1585KRASFAEKTAQLERTacetylation[1]
1885EEQAALHKADIEERLacetylation[3]
2155QAEQAALKQKQAADAacetylation[1]
2155QAEQAALKQKQAADAsuccinylation[1]
2496QKSFLSEKDSLLQREacetylation[1]
2496QKSFLSEKDSLLQREubiquitination[2]
2512FIEQEKAKLEQLFQDacetylation[1]
2512FIEQEKAKLEQLFQDsuccinylation[1]
2700SIAGLLLKPTNEKLSacetylation[1]
2762VGPELHHKLLSAERAacetylation[3]
2883RLLPLTDKAAKGGELacetylation[3]
2912TVSAPFGKFQGRTVTacetylation[1]
2912TVSAPFGKFQGRTVTubiquitination[2]
3096EKLLSAEKAVTGYRDacetylation[1]
3096EKLLSAEKAVTGYRDsuccinylation[1]
3096EKLLSAEKAVTGYRDubiquitination[2]
3161YARGYLDKETNRALTacetylation[1]
3161YARGYLDKETNRALTubiquitination[2]
3211SLLPLSEKAVRARQEubiquitination[2]
3234RETLEQAKVEVPVGSubiquitination[2]
3243EVPVGSFKGRAMTVWacetylation[1]
3243EVPVGSFKGRAMTVWsuccinylation[1]
3243EVPVGSFKGRAMTVWubiquitination[2]
3317ASELLDAKILSRAQFacetylation[4]
3317ASELLDAKILSRAQFubiquitination[2]
3421VGPELHEKLLSAEKAacetylation[3, 4]
3433EKAVTGYKDPYSGNTacetylation[3]
3784SLFQAMKKELIPAEEacetylation[4]
3827YQRGYLNKDTHDQLSacetylation[4]
4339VNKGLVDKIMVDRINubiquitination[2]
4350DRINLAQKAFCGFEDacetylation[4]
4468EAAAQSSKGYYSPYSubiquitination[2]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [4] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [5] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 4543 AA 
Protein Sequence
MEPSGSLFPS LVVVGHVVTL AAVWHWRKGH RQAKDEQDER DRVQKKTFTK WVNKHLIKAQ 60
RHISDLYEDL RDGHNLISLL EVLSGDSLPR EKGRMRFHKL QNVQIALDYL RHRQVKLVNI 120
RNDDIADGNP KLTLGLIWTI ILHFQISDIQ VSGQSEDMTA KEKLLLWSQR MVEGYQGLRC 180
DNFTTSWRDG RLFNAIIHRH KPMLIDMNKV YRQTNLENLD QAFSVAERDL GVTRLLDPED 240
VDVPQPDEKS IITYVSSLYD AMPRVPGAQD GVRANELQLR WQEYRELVLL LLQWIRHHTA 300
AFEERKFPSS FEEIEILWCQ FLKFKETELP AKEADKNRSK VIYQSLEGAV QAGQLKIPPG 360
YHPLDVEKEW GKLHVAILER EKQLRSEFER LECLQRIVSK LQMEAGLCEE QLNQADALLQ 420
SDIRLLASGK VAQRAGEVER DLDKADGMIR LLFNDVQTLK DGRHPQGEQM YRRVYRLHER 480
LVAIRTEYNL RLKAGVGAPV TQVTLQSTQR RPELEDSTLR YLQDLLAWVE ENQRRIDSAE 540
WGVDLPSVEA QLGSHRGMHQ SIEEFRAKIE RARNDESQLS PATRGAYRDC LGRLDLQYAK 600
LLNSSKARLR SLESLHGFVA AATKELMWLN EKEEEEVGFD WSDRNTNMAA KKESYSALMR 660
ELEMKEKKIK EIQNTGDRLL REDHPARPTV ESFQAALQTQ WSWMLQLCCC IEAHLKENTA 720
YFQFFSDVRE AEEQLQKLQE TLRRKYSCDR TITVTRLEDL LQDAQDEKEQ LNEYKGHLSG 780
LAKRAKAIVQ LKPRNPAHPV RGHVPLIAVC DYKQVEVTVH KGDQCQLVGP AQPSHWKVLS 840
GSSSEAAVPS VCFLVPPPNQ EAQEAVARLE AQHQALVTLW HQLHVDMKSL LAWQSLSRDI 900
QLIRSWSLVT FRTLKPEEQR QALRNLELHY QAFLRDSQDA GGFGPEDRLV AEREYGSCSR 960
HYQQLLQSLE QGEQEESRCQ RCISELKDIR LQLEACETRT VHRLRLPLDK DPARECAQRI 1020
AEQQKAQAEV EGLGKGVARL SAEAEKVLAL PEPSPAAPTL RSELELTLGK LEQVRSLSAI 1080
YLEKLKTISL VIRSTQGAEE VLKTHEEQLK EAQAVPATLQ ELEATKASLK KLRAQAEAQQ 1140
PVFNTLRDEL RGAQEVGERL QQRHGERDVE VERWRERVTQ LLERWQAVLA QTDVRQRELE 1200
QLGRQLRYYR ESADPLSAWL QDAKRRQEQI QAVPIANCQA AREQLRQEKA LLEEIERHGE 1260
KVEECQKFAK QYINAIKDYE LQLITYKAQL EPVASPAKKP KVQSGSESVI QEYVDLRTRY 1320
SELTTLTSQY IKFISETLRR MEEEERLAEQ QRAEERERLA EVEAALEKQR QLAEAHAQAK 1380
AQAELEAQEL QRRMQEEVAR REEAAVDAQQ QKRSIQEELQ HLRQSSEAEI QAKAQQVEAA 1440
ERSRMRIEEE IRVVRLQLET TERQRGGAEG ELQALRARAE EAEAQKRQAQ EEAERLRRQV 1500
QDESQRKRQA EAELALRVKA EAEAAREKQR ALQALDELRL QAEEAERRLR QAEAERARQV 1560
QVALETAQRS AEVELQSKRA SFAEKTAQLE RTLQEEHVTV AQLREEAERR AQQQAEAERA 1620
REEAERELER WQLKANEALR LRLQAEEVAQ QKSLAQADAE KQKEEAEREA RRRGKAEEQA 1680
VRQRELAEQE LEKQRQLAEG TAQQRLAAEQ ELIRLRAETE QGEQQRQLLE EELARLQHEA 1740
TAATQKRQEL EAELAKVRAE MEVLLASKAR AEEESRSTSE KSKQRLEAEA GRFRELAEEA 1800
ARLRALAEEA KRQRQLAEED AARQRAEAER VLTEKLAAIS EATRLKTEAE IALKEKEAEN 1860
ERLRRLAEDE AFQRRRLEEQ AALHKADIEE RLAQLRKASE SELERQKGLV EDTLRQRRQV 1920
EEEIMALKVS FEKAAAGKAE LELELGRIRS NAEDTMRSKE QAELEAARQR QLAAEEEQRR 1980
REAEERVQRS LAAEEEAARQ RKVALEEVER LKAKVEEARR LRERAEQESA RQLQLAQEAA 2040
QKRLQAEEKA HAFVVQQREE ELQQTLQQEQ NMLDRLRSEA EAARRAAEEA EEAREQAERE 2100
AAQSRKQVEE AERLKQSAEE QAQAQAQAQA AAEKLRKEAE QEAARRAQAE QAALKQKQAA 2160
DAEMEKHKKF AEQTLRQKAQ VEQELTTLRL QLEETDHQKS ILDEELQRLK AEVTEAARQR 2220
SQVEEELFSV RVQMEELGKL KARIEAENRA LILRDKDNTQ RFLEEEAEKM KQVAEEAARL 2280
SVAAQEAARL RQLAEEDLAQ QRALAEKMLK EKMQAVQEAT RLKAEAELLQ QQKELAQEQA 2340
RRLQEDKEQM AQQLVEETQG FQRTLEAERQ RQLEMSAEAE RLKLRMAEMS RAQARAEEDA 2400
QRFRKQAEEI GEKLHRTELA TQEKVTLVQT LEIQRQQSDH DAERLREAIA ELEREKEKLK 2460
QEAKLLQLKS EEMQTVQQEQ ILQETQALQK SFLSEKDSLL QRERFIEQEK AKLEQLFQDE 2520
VAKAKQLREE QQRQQQQMEQ EKQELMASME EARRRQREAE EGVRRKQEEL QHLEQQRQQQ 2580
EKLLAEENQR LRERLQRLEE EHRAALAHSE IATTQAASTK ALPNGRDAPD GPSVEAEPEY 2640
TFEGLRQKVP AQQLQEAGIL SQEELQRLAQ GHTTVAELTQ REDVYRYLKG RSSIAGLLLK 2700
PTNEKLSVYT ALQRQLLSPG TALILLEAQA ASGFLLDPVR NRRLTVNEAV KEGVVGPELH 2760
HKLLSAERAV TGYKDPYTGE QISLFQAMKK DLIVRDHGVR LLEAQIATGG IIDPVHSHRV 2820
PVDVAYKRGY FDEEMNRILS DPSDDTKGFF DPNTHENLTY LQLLERCVED PETGLRLLPL 2880
TDKAAKGGEL VYTDTEARDV FEKATVSAPF GKFQGRTVTI WEIINSEYFT AEQRRDLLQQ 2940
FRTGHITVEK IIKIVITVVE EHERKGQLCF EGLRALVPAA ELLDSGVISH ELYQQLQRGE 3000
RSVREVAEAD SVRQALRGTN VIAGVWLEEA GQKLSIYEAL KKDLLQPEVA VALLEAQAGT 3060
GHIIDPATSA RLTVDEAVRA GLVGPELHEK LLSAEKAVTG YRDPYSGQSV SLFQALKKGL 3120
IPREQGLRLL DAQLSTGGIV DPSKSHRVPL DVAYARGYLD KETNRALTSP RDDARVYHDP 3180
STQEPVTYSQ LQQRCRSDQL TGLSLLPLSE KAVRARQEEV YSELQARETL EQAKVEVPVG 3240
SFKGRAMTVW ELISSEYFTE EQRQELLRQF RTGKVTVEKV IKIVITIVEE VETRRQERLS 3300
FSGLRAPVPA SELLDAKILS RAQFDQLKDG KTSVKELSEV GSVRTLLQGS GCLAGIYLED 3360
SKEKVTIYEA MRRGLLRPST ATLLLEAQAA TGFLVDPVRN QRLYVHEAVK AGVVGPELHE 3420
KLLSAEKAVT GYKDPYSGNT ISLFQAMKKG LVLRDHAIRL LEAQVATGGI IDPVHSHRLP 3480
VDVAYQRGYF DEEMNRVLAD PSDDTKGFFD PNTHENLTYL QLLERCVEDP ETGLRLLPLK 3540
GAEKTEVVET TQVYTEEETR RAFEETQIDI PGGGSHGGSS MSLWEVMQSN MIPEDQRARL 3600
MADFQAGRVT KERMIIIIIE IIEKTEIIRQ QNLASYDYVR RRLTAEDLYE ARIISLETYN 3660
LFREGTKNLR EVLEMESAWR YLYGTGAVAG VYLPGSRQTL TIYQALKKGL LSAEVARLLL 3720
EAQAATGFLL DPVKGERLTV DEAVRKGLVG PELHDRLLSA ERAVTGYRDP YTEQTISLFQ 3780
AMKKELIPAE EALRLLDAQL ATGGIVDPRL GFHLPLEVAY QRGYLNKDTH DQLSEPSEVR 3840
SYVDPSTDER LSYTQLLKRC RRDDPSGQML LLLSDARKLT FRGLRKQITV EELVRSQVMD 3900
EATALQLQEG LTSIEEVTKN LQKFLEGTSC IAGVFVDATK ERLSVYQAMK KGIIRPGTAF 3960
ELLEAQAATG YVIDPIKGLK LTVEEAVRMG IVGPEFKDKL LSAERAVTGY KDPYSGKLIS 4020
LFQAMKKGLI LKDHGIRLLE AQIATGGIID PEESHRLPVE VAYKRGLFDE EMNEILTDPS 4080
DDTKGFFDPN TEENLTYLQL MERCITDPQT GLCLLPLKEK KRERKTSSKS SVRKRRVVIV 4140
DPETGKEMSV YEAYRKGLID HQTYLELSEQ ECEWEEITIS SSDGVVKSMI IDRRSGRQYD 4200
IDDAITKNLI DRSALDQYRA GTLSITEFAD MLSGNAGGFR SRSSSVGSSS SYPISSAGPR 4260
TQLASWSDPT EETGPVAGIL DTETLEKVSI TEAMHRNLVD NITGQRLLEA QACTGGIIDP 4320
STGERFPVTE AVNKGLVDKI MVDRINLAQK AFCGFEDPRT KTKMSAAQAL KKGWLYYEAG 4380
QRFLEVQYLT GGLIEPDTPG RVSLDEALQR GTVDARTAQK LRDVSAYSKY LTCPKTKLKI 4440
SYKDALDRSM VEEGTGLRLL EAAAQSSKGY YSPYSVSGSG STAGSRTGSR TGSRAGSRRG 4500
SFDATGSGFS MTFSSSSYSS SGYGRRYASG PSASLGGPES AVA 4543 
Gene Ontology
 GO:0043292; C:contractile fiber; IDA:MGI.
 GO:0005856; C:cytoskeleton; IEA:InterPro. 
Interpro
 IPR001589; Actinin_actin-bd_CS.
 IPR001715; CH-domain.
 IPR001101; Plectin_repeat.
 IPR018159; Spectrin/alpha-actinin. 
Pfam
 PF00307; CH
 PF00681; Plectin 
SMART
 SM00033; CH
 SM00250; PLEC
 SM00150; SPEC 
PROSITE
 PS00019; ACTININ_1
 PS00020; ACTININ_2
 PS50021; CH 
PRINTS