CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023382
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dipeptidyl peptidase 3 
Protein Synonyms/Alias
 Dipeptidyl aminopeptidase III; Dipeptidyl arylamidase III; Dipeptidyl peptidase III; DPP III 
Gene Name
 DppIII 
Gene Synonyms/Alias
 CG7415 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
311VTRGDYQKLLQRVNQacetylation[1]
325QHLLQAQKYAANENEacetylation[1]
529NGVYNFDKENTKNLVacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Degrades neuropeptide proctolin (RYLPT) by cleavage between Tyr and Leu residues. 
Sequence Annotation
 ACT_SITE 507 507 By similarity.
 METAL 506 506 Zinc; catalytic (By similarity).
 METAL 511 511 Zinc; catalytic (By similarity).  
Keyword
 Alternative splicing; Aminopeptidase; Cell membrane; Complete proteome; Cytoplasm; Hydrolase; Membrane; Metal-binding; Metalloprotease; Protease; Reference proteome; Transmembrane; Transmembrane helix; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 786 AA 
Protein Sequence
MFWLRGLQRS RQQLNRLCHF RSRLNYGTSP SIRSVQPSIS RSLGFCSSLV RYSCSTNLPQ 60
PAEMASKTAH FVLPNTQPIA DLDCKSAFEN LTEKEKLYAH HFSQASWDGG LIALIQSSPE 120
APLIFSLLHR IFLAEKIPVL RAKALEAGVS ADDFTAFLVY ACGVFANAGN YKGMGDSKIV 180
PNLSEKQFET IVKASAAYSD EPRVGKIFEK VKNLIYALES RNEILGFAPD GITTYWSDNC 240
TKEDSEIVNA WLTSKRIEPY MCRTFKIVEN GQTVYDVKLG SVAESTQDGI TLPLEEYNGN 300
KFRVTRGDYQ KLLQRVNQHL LQAQKYAANE NESKMIEHYV RSFEQGSLDE HKNGSRWWIK 360
DKGPVIETYI GFIETYRDPA GGRAEFEGFV AMVNKESSAK FSELVNRAEK LIEYLPWTEP 420
YEKDSYLKPD FTSLDVLTFA GSGVPAGINI PNYDEIRQDE GFKNVSLGNV LANINRKDPI 480
PFLTEEDQTL MKEYKVKAFE VQVGLHELLG HGSGKLFRID ENGVYNFDKE NTKNLVTGEP 540
ITKWYLPGET YDTKFGAIGS SYEECRAEAV GLYLSLQRDI LEIFGFKDKA EQDNIIYVNW 600
LSLIWNGMGV ALEMFNPKSK LWLQAHSRAR FVIMKVLLEA GEGLVKVEET EKGKNLLLTV 660
DRSKIDTVGR KALGDFLTKL QVYKSTADIE AASKMYEHYS KVDESGSHPW AKWRDICLAH 720
KKPRMILVQA NTAIGQDQKV QLKTYEPTHE GYIQSWVERY PNTDIDDLLE SIVEKDKKYF 780
PTAFNN 786 
Gene Ontology
 GO:0005829; C:cytosol; IDA:FlyBase.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0016020; C:membrane; IDA:FlyBase.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
 GO:0008239; F:dipeptidyl-peptidase activity; IDA:FlyBase.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IDA:FlyBase. 
Interpro
 IPR005317; Dipeptidyl-peptase3. 
Pfam
  
SMART
  
PROSITE
  
PRINTS