| Tag | Content |
|---|
| CPLM ID | CPLM-016908 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Integrator complex subunit 4 |
Protein Synonyms/Alias | Int4 |
Gene Name | Ints4 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 27 | QQEEIATKKLRLTKP | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). |
Sequence Annotation | REPEAT 67 106 HEAT 1.
REPEAT 146 184 HEAT 2.
REPEAT 191 229 HEAT 3.
REPEAT 230 264 HEAT 4.
REPEAT 278 314 HEAT 5.
REPEAT 370 406 HEAT 6.
REPEAT 407 445 HEAT 7.
REPEAT 447 485 HEAT 8. |
Keyword | Alternative splicing; Complete proteome; Nucleus; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 964 AA |
Protein Sequence | MAAHLKKRVY EEFTKVVQQQ QEEIATKKLR LTKPSKSAAL HIDLCKATSP ADALQYLLQF 60
ARKPVEAESV EGVVRILLEH YYKENDPSVR LKIASLLGLL SKTAGFSPDC IMDDAINILQ 120
NEKSHQVLAQ LLDTLLAIGS KLPENQATQV RLVDVACKHL TDTSHGVRNK CLQLLGNLGS 180
LEKSVTKDTE GSAARDVQKI IGDHFSDQDP RVRTAAIKAM LQLHERGLKL HQTIYNQACK 240
LLSDDYEQVR SAAVQLIWVV SQLYPESIVP IPSSNEEIRL VDDAFGKICH MVSDGSWVVR 300
VQAAKLLGSM EQVSSHFLEQ TLDKKLMSDL RRKRTAHERA KELYSSGEFS SGRKWGDDAP 360
KEEIDTGAVN LIESGACGAF VHGLEDEMYE VRIAAVEALC MLAQSSPSFA EKCLDFLVDM 420
FNDEIEEVRL QSIHTMRKIS NNITLREDQL DTVLAVLEDS SRDIREALHE LLCCTNVSTK 480
EGIHLALVEL LKNLTKYPTD RDSIWKCLKF LGSRHPTLVL PLVPELLSTH PFFDTAEPDM 540
DDPAYIAVLV LIFNAAKTCP TMPALFSDHT LRHYAYLRDS LSHLVPALRL PGRKLVSSTV 600
PSNITPHEDP SQQFLQQSLE RVYSVQHLDP QGAQELLEFT IRDLQRLGEL QSELAGVADF 660
SATYLQCQLL LIKALQEKLW NVAAPLYLKQ SDLASAAAKQ IMEETYKMEF MYSGVENKQV 720
VIIQHMRLQA KALQLIVTAR TTRGVDPLFG MCEKFLQEVD FFQRCFIADL PHLQDSFVDK 780
LLDLMPRLMA SKPVEVIKIL QTMLRQSTFL HLPLPEQIHK ASATIIEPAG ESDNPLRFTS 840
GLVVALDVDA TLEHVQDPQN TVKVQVLYPD GQAQMIHPKP ADFRNPGPGR HRLLTQVYLS 900
HTAWTEPCQV EVRLLLAYNS GARIPKSPWL EGSEMSPQVE TSIEGTIPFS KPVKVYIMPK 960
PARR 964 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |