UniProt Accession

 ACM1_MOUSE; P12657; Q52KQ0; Q8BJN3 

Genbank Protein ID

 J04192; AK081248; AK138282; AC025794; CH466612; CH466612; BC094242 

Genbank Nucleotide ID

 AAA37158.1; BAC38175.1; BAE23612.1; EDL33348.1; EDL33349.1; AAH94242.1 

Protein Name

 Muscarinic acetylcholine receptor M1 

Protein Synonyms/Alias

  

Gene Name

 Chrm1 

Gene Synonyms/Alias

 Chrm-1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
233	QGSETPGKGGGSSSS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. 

Sequence Annotation

 MOD_RES 451 451 Phosphoserine (Potential).
 MOD_RES 455 455 Phosphothreonine (Potential).
 MOD_RES 457 457 Phosphoserine (Potential).
 CARBOHYD 2 2 N-linked (GlcNAc...) (Probable).
 CARBOHYD 12 12 N-linked (GlcNAc...) (Probable).
 DISULFID 98 178 By similarity.  

Keyword

 Cell junction; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Synapse; Transducer; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 460 AA 

Protein Sequence

Gene Ontology

 GO:0032279; C:asymmetric synapse; IEA:Compara.
 GO:0043679; C:axon terminus; IEA:Compara.
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0014069; C:postsynaptic density; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0016907; F:G-protein coupled acetylcholine receptor activity; IEA:Compara.
 GO:0007274; P:neuromuscular synaptic transmission; IEA:Compara.
 GO:0043270; P:positive regulation of ion transport; ISO:MGI.
 GO:0060079; P:regulation of excitatory postsynaptic membrane potential; IEA:InterPro.
 GO:0040012; P:regulation of locomotion; IMP:MGI.
 GO:1900274; P:regulation of phospholipase C activity; IEA:InterPro. 

Interpro

 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR002228; Musac_Ach_M1_rcpt.
 IPR000995; Musac_Ach_rcpt. 

Pfam

 PF00001; 7tm_1 

SMART

  

PROSITE

 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 

PRINTS

 PR00237; GPCRRHODOPSN.
 PR00243; MUSCARINICR.
 PR00538; MUSCRINICM1R.