CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022980
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 V-type proton ATPase subunit H 
Protein Synonyms/Alias
 V-ATPase subunit H; Nef-binding protein 1; NBP1; Protein VMA13 homolog; V-ATPase 50/57 kDa subunits; Vacuolar proton pump subunit H; Vacuolar proton pump subunit SFD 
Gene Name
 ATP6V1H 
Gene Synonyms/Alias
 CGI-11 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
323DIKFLLEKLGESVQDubiquitination[1]
342DEYSSELKSGRLEWSubiquitination[1]
378ELLKILTKLLEVSDDubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates the ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes. 
Sequence Annotation
 MOD_RES 483 483 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Host-virus interaction; Hydrogen ion transport; Ion transport; Phosphoprotein; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 483 AA 
Protein Sequence
MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISAEDCEFI QRFEMKRSPE 60
EKQEMLQTEG SQCAKTFINL MTHICKEQTV QYILTMVDDM LQENHQRVSI FFDYARCSKN 120
TAWPYFLPML NRQDPFTVHM AARIIAKLAA WGKELMEGSD LNYYFNWIKT QLSSQSSQYV 180
QCVAGCLQLM LRVNEYRFAW VEADGVNCIM GVLSNKCGFQ LQYQMIFSIW LLAFSPQMCE 240
HLRRYNIIPV LSDILQESVK EKVTRIILAA FRNFLEKSTE RETRQEYALA MIQCKVLKQL 300
ENLEQQKYDD EDISEDIKFL LEKLGESVQD LSSFDEYSSE LKSGRLEWSP VHKSEKFWRE 360
NAVRLNEKNY ELLKILTKLL EVSDDPQVLA VAAHDVGEYV RHYPRGKRVI EQLGGKQLVM 420
NHMHHEDQQV RYNALLAVQK LMVHNWEYLG KQLQSEQPQT AAARS 465 
Gene Ontology
 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0000221; C:vacuolar proton-transporting V-type ATPase, V1 domain; NAS:UniProtKB.
 GO:0030234; F:enzyme regulator activity; NAS:UniProtKB.
 GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
 GO:0006200; P:ATP catabolic process; NAS:GOC.
 GO:0015991; P:ATP hydrolysis coupled proton transport; NAS:UniProtKB.
 GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome.
 GO:0006897; P:endocytosis; IDA:UniProtKB.
 GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.
 GO:0051701; P:interaction with host; TAS:Reactome.
 GO:0090382; P:phagosome maturation; TAS:Reactome.
 GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.
 GO:0033572; P:transferrin transport; TAS:Reactome.
 GO:0007035; P:vacuolar acidification; NAS:UniProtKB.
 GO:0016032; P:viral reproduction; TAS:Reactome.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR004908; ATPase_V1-cplx_hsu.
 IPR011987; ATPase_V1-cplx_hsu_C. 
Pfam
 PF11698; V-ATPase_H_C
 PF03224; V-ATPase_H_N 
SMART
  
PROSITE
  
PRINTS