CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037770
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase 
Protein Synonyms/Alias
  
Gene Name
 TYK2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
22IPLEEVAKKTSFKDCubiquitination[1]
23PLEEVAKKTSFKDCIubiquitination[1]
169PQASLFGKKAKAHKAubiquitination[1]
216SIHRQDNKCLELSLPubiquitination[1]
319MQSLRLRKFPIEQQDubiquitination[1]
402SFHRVDQKEITQLSHubiquitination[1]
543ALSYLENKNLVHGNVubiquitination[1]
571EGTSPFIKLSDPGVGubiquitination[1, 2]
638QSRSPSEKEHFYQRQubiquitination[1]
745TGEMVAVKALKADCGubiquitination[1]
760PQHRSGWKQEIDILRubiquitination[1]
861IGDFGLAKAVPEGHEubiquitination[1]
990ILKTVHEKYQGQAPSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1002 AA 
Protein Sequence
MAFLHLCHLA LRHGIPLEEV AKKTSFKDCI PRSFRRHIRQ HSALTRLRLR NVFRRFLRDF 60
QPGRLSQQMV MVKYLATLER LAPRFGTERV PVCHLRLLAQ AEGEPCYIRD SGVAPTDPGP 120
ESAAGPPTHE VLVTGTGGIQ WWPVEEEVNK EEGSSGSSGR NPQASLFGKK AKAHKAVGQP 180
ADRPREPLWA YFCDFRDITH VVLKEHCVSI HRQDNKCLEL SLPSRAAALS FVSLVDGYFR 240
LTADSSHYLC HEVAPPRLVM SIRDGIHGPL LEPFVQAKLR PEDGLYLIHW STSHPYRLIL 300
TVAQRSQAPD GMQSLRLRKF PIEQQDGAFV LEGWGRSFPS VRELGAALQG CLLRAGDDCF 360
SLRRCCLPQP GETSNLIIMR GARASPRTLN LSQLSFHRVD QKEITQLSHL GQGTRTNVYE 420
GRLRVEGSGD PEEGKMDDED PLVPGRDRGQ ELRVVLKVLD PSHHDIALAF YETASLMSQV 480
SHTHLAFVHG VCVRGPENIM VTEYVEHGPL DVWLRRERGH VPMAWKMVVA QQLASALSYL 540
ENKNLVHGNV CGRNILLARL GLAEGTSPFI KLSDPGVGLG ALSREERVER IPWLAPECLP 600
GGANSLSTAM DKWGFGATLL EICFDGEAPL QSRSPSEKEH FYQRQHRLPE PSCPQLATLT 660
SQCLTYEPTQ RPSFRTILRD LTRLQPHNLA DVLTVNPDSP ASDPTVFHKR YLKKIRDLGE 720
GHFGKVSLYC YDPTNDGTGE MVAVKALKAD CGPQHRSGWK QEIDILRTLY HEHIIKYKGC 780
CEDQGEKSLQ LVMEYVPLGS LRDYLPRHSI GLAQLLLFAQ QICEGMAYLH AQHYIHRDLA 840
ARNVLLDNDR LVKIGDFGLA KAVPEGHEYY RVREDGDSPV FWYAPECLKE YKFYYASDVW 900
SFGVTLYELL THCDSSQSPP TKFLELIGIA QGQMTVLRLT ELLERGERLP RPDKCPCEVY 960
HLMKNCWETE ASFRPTFENL IPILKTVHEK YQGQAPSVFS VC 1002 
Gene Ontology
 GO:0005856; C:cytoskeleton; IEA:InterPro.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
 GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro. 
Interpro
 IPR000299; FERM_domain.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR000980; SH2.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
 IPR016045; Tyr_kinase_non-rcpt_TYK2_N. 
Pfam
 PF07714; Pkinase_Tyr 
SMART
 SM00252; SH2
 SM00219; TyrKc 
PROSITE
 PS50057; FERM_3
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR 
PRINTS
 PR01823; JANUSKINASE.
 PR00109; TYRKINASE.
 PR01827; YKINASETYK2.