| Tag | Content |
|---|
| CPLM ID | CPLM-005326 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tenascin |
Protein Synonyms/Alias | TN; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C |
Gene Name | TNC |
Gene Synonyms/Alias | HXB |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 453 | RGRCVEGKCVCEQGF | ubiquitination | [1] | | 461 | CVCEQGFKGYDCSDM | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. |
Sequence Annotation | DOMAIN 174 186 EGF-like 1; incomplete.
DOMAIN 186 217 EGF-like 2.
DOMAIN 217 248 EGF-like 3.
DOMAIN 248 280 EGF-like 4.
DOMAIN 280 311 EGF-like 5.
DOMAIN 311 342 EGF-like 6.
DOMAIN 342 373 EGF-like 7.
DOMAIN 373 404 EGF-like 8.
DOMAIN 404 435 EGF-like 9.
DOMAIN 435 466 EGF-like 10.
DOMAIN 466 497 EGF-like 11.
DOMAIN 497 528 EGF-like 12.
DOMAIN 528 559 EGF-like 13.
DOMAIN 559 590 EGF-like 14.
DOMAIN 590 621 EGF-like 15.
DOMAIN 622 710 Fibronectin type-III 1.
DOMAIN 713 801 Fibronectin type-III 2.
DOMAIN 802 891 Fibronectin type-III 3.
DOMAIN 892 983 Fibronectin type-III 4.
DOMAIN 984 1071 Fibronectin type-III 5.
DOMAIN 1075 1162 Fibronectin type-III 6.
DOMAIN 1164 1253 Fibronectin type-III 7.
DOMAIN 1255 1344 Fibronectin type-III 8.
DOMAIN 1348 1435 Fibronectin type-III 9.
DOMAIN 1439 1526 Fibronectin type-III 10.
DOMAIN 1528 1617 Fibronectin type-III 11.
DOMAIN 1619 1708 Fibronectin type-III 12.
DOMAIN 1709 1797 Fibronectin type-III 13.
DOMAIN 1798 1885 Fibronectin type-III 14.
DOMAIN 1886 1973 Fibronectin type-III 15.
DOMAIN 1975 2190 Fibrinogen C-terminal.
MOD_RES 70 70 Phosphoserine (By similarity).
MOD_RES 72 72 Phosphoserine (By similarity).
CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
CARBOHYD 166 166 N-linked (GlcNAc...) (Potential).
CARBOHYD 184 184 N-linked (GlcNAc...).
CARBOHYD 327 327 N-linked (GlcNAc...) (Potential).
CARBOHYD 788 788 N-linked (GlcNAc...) (Potential).
CARBOHYD 1018 1018 N-linked (GlcNAc...).
CARBOHYD 1034 1034 N-linked (GlcNAc...).
CARBOHYD 1079 1079 N-linked (GlcNAc...).
CARBOHYD 1093 1093 N-linked (GlcNAc...).
CARBOHYD 1119 1119 N-linked (GlcNAc...) (Potential).
CARBOHYD 1184 1184 N-linked (GlcNAc...).
CARBOHYD 1210 1210 N-linked (GlcNAc...) (Potential).
CARBOHYD 1261 1261 N-linked (GlcNAc...).
CARBOHYD 1275 1275 N-linked (GlcNAc...).
CARBOHYD 1301 1301 N-linked (GlcNAc...).
CARBOHYD 1366 1366 N-linked (GlcNAc...).
CARBOHYD 1392 1392 N-linked (GlcNAc...) (Potential).
CARBOHYD 1445 1445 N-linked (GlcNAc...) (Potential).
CARBOHYD 1455 1455 N-linked (GlcNAc...) (Potential).
CARBOHYD 1485 1485 N-linked (GlcNAc...).
CARBOHYD 1534 1534 N-linked (GlcNAc...) (Potential).
CARBOHYD 1809 1809 N-linked (GlcNAc...).
CARBOHYD 2162 2162 N-linked (GlcNAc...).
DISULFID 190 200 By similarity.
DISULFID 194 205 By similarity.
DISULFID 207 216 By similarity.
DISULFID 221 231 By similarity.
DISULFID 225 236 By similarity.
DISULFID 238 247 By similarity.
DISULFID 252 263 By similarity.
DISULFID 256 268 By similarity.
DISULFID 270 279 By similarity.
DISULFID 284 294 By similarity.
DISULFID 288 299 By similarity.
DISULFID 301 310 By similarity.
DISULFID 315 325 By similarity.
DISULFID 319 330 By similarity.
DISULFID 332 341 By similarity.
DISULFID 346 356 By similarity.
DISULFID 350 361 By similarity.
DISULFID 363 372 By similarity.
DISULFID 377 387 By similarity.
DISULFID 381 392 By similarity.
DISULFID 394 403 By similarity.
DISULFID 408 418 By similarity.
DISULFID 412 423 By similarity.
DISULFID 425 434 By similarity.
DISULFID 439 449 By similarity.
DISULFID 443 454 By similarity.
DISULFID 456 465 By similarity.
DISULFID 470 480 By similarity.
DISULFID 474 485 By similarity.
DISULFID 487 496 By similarity.
DISULFID 501 511 By similarity.
DISULFID 505 516 By similarity.
DISULFID 518 527 By similarity.
DISULFID 532 542 By similarity.
DISULFID 536 547 By similarity.
DISULFID 549 558 By similarity.
DISULFID 563 573 By similarity.
DISULFID 567 578 By similarity.
DISULFID 580 589 By similarity.
DISULFID 594 604 By similarity.
DISULFID 598 609 By similarity.
DISULFID 611 620 By similarity. |
Keyword | 3D-structure; Alternative splicing; Cell adhesion; Coiled coil; Complete proteome; Direct protein sequencing; Disulfide bond; EGF-like domain; Extracellular matrix; Glycoprotein; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 2201 AA |
Protein Sequence | MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV 60
GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK 120
ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW 180
KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE 240
GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV 300
CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ 360
CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN 420
GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC 480
VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG 540
RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN 600
LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH 660
EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF 720
KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE 780
ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK 840
DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR 900
RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE 960
YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS 1020
LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TAKEPEIGNL 1080
NVSDITPESF NLSWMATDGI FETFTIEIID SNRLLETVEY NISGAERTAH ISGLPPSTDF 1140
IVYLSGLAPS IRTKTISATA TTEAEPEVDN LLVSDATPDG FRLSWTADEG VFDNFVLKIR 1200
DTKKQSEPLE ITLLAPERTR DITGLREATE YEIELYGISK GRRSQTVSAI ATTAMGSPKE 1260
VIFSDITENS ATVSWRAPTA QVESFRITYV PITGGTPSMV TVDGTKTQTR LVKLIPGVEY 1320
LVSIIAMKGF EESEPVSGSF TTALDGPSGL VTANITDSEA LARWQPAIAT VDSYVISYTG 1380
EKVPEITRTV SGNTVEYALT DLEPATEYTL RIFAEKGPQK SSTITAKFTT DLDSPRDLTA 1440
TEVQSETALL TWRPPRASVT GYLLVYESVD GTVKEVIVGP DTTSYSLADL SPSTHYTAKI 1500
QALNGPLRSN MIQTIFTTIG LLYPFPKDCS QAMLNGDTTS GLYTIYLNGD KAEALEVFCD 1560
MTSDGGGWIV FLRRKNGREN FYQNWKAYAA GFGDRREEFW LGLDNLNKIT AQGQYELRVD 1620
LRDHGETAFA VYDKFSVGDA KTRYKLKVEG YSGTAGDSMA YHNGRSFSTF DKDTDSAITN 1680
CALSYKGAFW YRNCHRVNLM GRYGDNNHSQ GVNWFHWKGH EHSIQFAEMK LRPSNFRNLE 1740
GRRKRA 1746 |
Gene Ontology | GO:0005604; C:basement membrane; IEA:Compara. GO:0005615; C:extracellular space; IDA:BHF-UCL. GO:0005614; C:interstitial matrix; IEA:Compara. GO:0007155; P:cell adhesion; TAS:ProtInc. GO:0060739; P:mesenchymal-epithelial cell signaling involved in prostate gland development; IEA:Compara. GO:0007528; P:neuromuscular junction development; IEA:Compara. GO:0014012; P:peripheral nervous system axon regeneration; IEA:Compara. GO:0008284; P:positive regulation of cell proliferation; IEA:Compara. GO:0010628; P:positive regulation of gene expression; IEA:Compara. GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Compara. GO:0009611; P:response to wounding; IEP:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |