CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017604
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nitric oxide-associated protein 1 
Protein Synonyms/Alias
  
Gene Name
 NOA1 
Gene Synonyms/Alias
 C4orf14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
89EPQPTREKQLQELQQubiquitination[1, 2]
479MGTHKSTKQVELTAQubiquitination[3]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP. 
Sequence Annotation
 MOD_RES 77 77 Phosphotyrosine.  
Keyword
 Apoptosis; Complete proteome; GTP-binding; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 698 AA 
Protein Sequence
MLPARLPFRL LSLFLRGSAP TAARHGLREP LLERRCAAAS SFQHSSSLGR ELPYDPVDTE 60
GFGEGGDMQE RFLFPEYILD PEPQPTREKQ LQELQQQQEE EERQRQQRRE ERRQQNLRAR 120
SREHPVVGHP DPALPPSGVN CSGCGAELHC QDAGVPGYLP REKFLRTAEA DGGLARTVCQ 180
RCWLLSHHRR ALRLQVSREQ YLELVSAALR RPGPSLVLYM VDLLDLPDAL LPDLPALVGP 240
KQLIVLGNKV DLLPQDAPGY RQRLRERLWE DCARAGLLLA PGHQGPQRPV KDEPQDGENP 300
NPPNWSRTVV RDVRLISAKT GYGVEELISA LQRSWRYRGD VYLVGATNAG KSTLFNTLLE 360
SDYCTAKGSE AIDRATISPW PGTTLNLLKF PICNPTPYRM FKRHQRLKKD STQAEEDLSE 420
QEQNQLNVLK KHGYVVGRVG RTFLYSEEQK DNIPFEFDAD SLAFDMENDP VMGTHKSTKQ 480
VELTAQDVKD AHWFYDTPGI TKENCILNLL TEKEVNIVLP TQSIVPRTFV LKPGMVLFLG 540
AIGRIDFLQG NQSAWFTVVA SNILPVHITS LDRADALYQK HAGHTLLQIP MGGKERMAGF 600
PPLVAEDIML KEGLGASEAV ADIKFSSAGW VSVTPNFKDR LHLRGYTPEG TVLTVRPPLL 660
PYIVNIKGQR IKKSVAYKTK KPPSLMYNVR KKKGKINV 698 
Gene Ontology
 GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IDA:UniProtKB.
 GO:0003924; F:GTPase activity; IBA:RefGenome.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
 GO:0010941; P:regulation of cell death; IMP:UniProtKB.
 GO:0043457; P:regulation of cellular respiration; IMP:UniProtKB.
 GO:0042254; P:ribosome biogenesis; IBA:RefGenome. 
Interpro
 IPR006073; GTP_binding_domain.
 IPR027417; P-loop_NTPase. 
Pfam
 PF01926; MMR_HSR1 
SMART
  
PROSITE
  
PRINTS