| Tag | Content |
|---|
| CPLM ID | CPLM-029491 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 3 subunit D |
Protein Synonyms/Alias | eIF3d; Eukaryotic translation initiation factor 3 subunit 7; eIF-3-zeta |
Gene Name | EIF3D |
Gene Synonyms/Alias | EIF3S7 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 53 | TGATYQDKRYTNKYS | ubiquitination | [1] |
|
Reference | [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA. Mol Cell Proteomics. 2012 May;11(5):148-59. [ PMID: 22505724] |
Functional Description | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (By similarity). |
Sequence Annotation | |
Keyword | Cytoplasm; Initiation factor; Phosphoprotein; Protein biosynthesis. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 533 AA |
Protein Sequence | MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS 60
SQFGGGSQYA YFHEEDESSF QLVDTARTQK TAYQRNRMRF AQRNLRRDKD RRNMLQFNLQ 120
ILPKSAKQKE RERIRLQKSQ KPRDSSVEVR SDWEVKEEMD FPQLMKMRYL EVSEPQDIEC 180
CGALEYYDKA FDRITTRSEK PLRSIKRIFH TVTTTDDPVI RKLAKTQGNV FATDAILATL 240
MSCTRSVYSW DIVVQRVGSK LFFDKRDNSD FDLLTVSETA NEPPQDEGNS FNSPRNLAME 300
ATYINHNFSQ QCLRMGKERY NFPNPNPFVE DDMDKNEIAS VAYRYRRWKL GDDIDLIVRC 360
EHDGVMTGAN GEVSFINIKT LNEWDSRHCN GVDWRQKLDS QRGAVIATEL KNNSYKLARW 420
TCCALLAGSE YLKLGYVSRY HVKDSSRHVI LGTQQFKPNE FASQINLSVE NAWGILRCVI 480
DICMKLEEGK YLILKDPNKQ VIRVYSLPDG TFSSDEDEEE EEEEEEEEEE EET 533 |
Gene Ontology | GO:0016282; C:eukaryotic 43S preinitiation complex; IEA:HAMAP. GO:0033290; C:eukaryotic 48S preinitiation complex; IEA:HAMAP. GO:0005852; C:eukaryotic translation initiation factor 3 complex; IEA:HAMAP. GO:0003743; F:translation initiation factor activity; IEA:HAMAP. GO:0001732; P:formation of translation initiation complex; IEA:Compara. GO:0001731; P:formation of translation preinitiation complex; IEA:HAMAP. GO:0006446; P:regulation of translational initiation; IEA:HAMAP. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |