CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-024627
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Sorting nexin-5 
Protein Synonyms/Alias
  
Gene Name
 Snx5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
17QQEEDRSKLRSVSVDubiquitination[1]
158SSHPVLSKDRNFHVFacetylation[2]
180SVRRKNTKEMFGGFFubiquitination[1]
188EMFGGFFKSVVKSADubiquitination[1]
268VIKKYLLKVAELFEKubiquitination[1]
275KVAELFEKLRKVEGRacetylation[2]
275KVAELFEKLRKVEGRubiquitination[1]
290VSSDEDLKLTELLRYubiquitination[1]
337RLKSKDVKLAETHQQubiquitination[1]
385EMSELEIKHARNNVSacetylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 May be involved in several stages of intracellular trafficking. Plays a role in macropinocytosis. Plays a role in the internalization of EGFR after EGF stimulation (By similarity). 
Sequence Annotation
 DOMAIN 25 172 PX.
 DOMAIN 202 404 BAR.
 REGION 40 46 Phosphatidylinositol bisphosphate
 REGION 99 105 Phosphatidylinositol bisphosphate
 REGION 113 116 Phosphatidylinositol bisphosphate
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 275 275 N6-acetyllysine (By similarity).  
Keyword
 3D-structure; Acetylation; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endocytosis; Endosome; Lipid-binding; Membrane; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 404 AA 
Protein Sequence
MAAVPELLEQ QEEDRSKLRS VSVDLNVDPS LQIDIPDALS ERDKVKFTVH TKTTLPTFQS 60
PEFSVTRQHE DFVWLHDTLT ETTDYAGLII PPAPTKPDFD GPREKMQKLG EGEGSMTKEE 120
FAKMKQELEA EYLAVFKKTV SSHEVFLQRL SSHPVLSKDR NFHVFLEYDQ DLSVRRKNTK 180
EMFGGFFKSV VKSADEVLFS GVKEVDDFFE QEKNFLINYY NRIKDSCAKA DKMTRSHKNV 240
ADDYIHTAAC LHSLALEEPT VIKKYLLKVA ELFEKLRKVE GRVSSDEDLK LTELLRYYML 300
NIEAAKDLLY RRTKALIDYE NSNKALDKAR LKSKDVKLAE THQQECCQKF EQLSESAKEE 360
LINFKRKRVA AFRKNLIEMS ELEIKHARNN VSLLQSCIDL FKNN 404 
Gene Ontology
 GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
 GO:0031313; C:extrinsic to endosome membrane; ISS:UniProtKB.
 GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
 GO:0070685; C:macropinocytic cup; ISS:UniProtKB.
 GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.
 GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
 GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.
 GO:0007154; P:cell communication; IEA:InterPro.
 GO:0006907; P:pinocytosis; ISS:UniProtKB.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR001683; Phox.
 IPR014637; Snx5_Snx6.
 IPR015404; Vps5_C. 
Pfam
 PF00787; PX
 PF09325; Vps5 
SMART
 SM00312; PX 
PROSITE
 PS51021; BAR
 PS50195; PX 
PRINTS