| Tag | Content |
|---|
| CPLM ID | CPLM-014342 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipid phosphate phosphohydrolase 1 |
Protein Synonyms/Alias | 35 kDa PAP; mPAP; Hydrogen peroxide-inducible protein 53; Hic53; PAP2-alpha; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; PAP-2a; PAP2a |
Gene Name | Ppap2a |
Gene Synonyms/Alias | Hpic53; Lpp1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 261 | THSYKERKEEDPHTT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), diacyl glycerol pyrophosphate (DGPP), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > C-1-P > S-1-P. |
Sequence Annotation | CARBOHYD 142 142 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Hydrolase; Membrane; Reference proteome; Transmembrane; Transmembrane helix. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 283 AA |
Protein Sequence | MFDKTRLPYV ALDVICVLLA AMPMTILKLG KVYPFQRGFF CTDNSVKYPY HDSTIPSRIL 60
AILGLGLPIF SMSIGESLSV YFNVLHSNSF VGNPYIATIY KAVGAFLFGV SASQSLTDIA 120
KYTIGSLRPH FLAICNPDWS KINCSDGYIE DYICQGNEEK VKEGRLSFYS GHSSFSMYCM 180
LFVALYLQAR MKGDWARLLR PMLQFGLIAF SIYVGLSRVS DYKHHWSDVT VGLIQGAAMA 240
ILVALYVSDF FKDTHSYKER KEEDPHTTLH ETASSRNYST NHEP 284 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; TAS:MGI. GO:0008195; F:phosphatidate phosphatase activity; ISS:UniProtKB. GO:0006672; P:ceramide metabolic process; TAS:MGI. GO:0006651; P:diacylglycerol biosynthetic process; TAS:MGI. GO:0006470; P:protein dephosphorylation; IDA:MGI. GO:0007165; P:signal transduction; TAS:MGI. GO:0006670; P:sphingosine metabolic process; TAS:MGI. |
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PRINTS | |