UniProt Accession

 BL1S6_RAT; Q4V8A6 

Genbank Protein ID

 CH473949; BC097469 

Genbank Nucleotide ID

 EDL80048.1; AAH97469.1 

Protein Name

 Biogenesis of lysosome-related organelles complex 1 subunit 6 

Protein Synonyms/Alias

 BLOC-1 subunit 6; Pallid protein homolog; Pallidin 

Gene Name

 Bloc1s6 

Gene Synonyms/Alias

 Pldn 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
145	KLQQQRQKEELEREQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 172 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; ISS:UniProtKB.
 GO:0005768; C:endosome; IEA:Compara.
 GO:0019898; C:extrinsic to membrane; ISS:UniProtKB.
 GO:0031201; C:SNARE complex; IEA:Compara.
 GO:0030133; C:transport vesicle; ISS:UniProtKB.
 GO:0051015; F:actin filament binding; ISS:UniProtKB.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0008089; P:anterograde axon cargo transport; ISS:UniProtKB.
 GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
 GO:0007596; P:blood coagulation; IEA:Compara.
 GO:0006944; P:cellular membrane fusion; IEA:Compara.
 GO:0035646; P:endosome to melanosome transport; ISS:UniProtKB.
 GO:0030318; P:melanocyte differentiation; IEA:Compara.
 GO:0032402; P:melanosome transport; ISS:UniProtKB.
 GO:0031175; P:neuron projection development; ISS:UniProtKB.
 GO:0032816; P:positive regulation of natural killer cell activation; IEA:Compara.
 GO:0050942; P:positive regulation of pigment cell differentiation; ISS:UniProtKB.
 GO:0033299; P:secretion of lysosomal enzymes; IEA:Compara. 

Interpro

 IPR017242; BLOC-1_complex_pallidin. 

Pfam

  

SMART

  

PROSITE

  

PRINTS