CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031561
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Serine/threonine-protein kinase 38-like 
Protein Synonyms/Alias
 cDNA FLJ50384, highly similar to Serine/threonine-protein kinase 38-like (EC 2.7.11.1) 
Gene Name
 STK38L 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
17EVRLVQKKDTGHIYAubiquitination[1]
26TGHIYAMKILRKSDMubiquitination[1]
122GFIHRDIKPDNLLLDubiquitination[2]
131DNLLLDAKGHVKLSDubiquitination[2]
135LDAKGHVKLSDFGLCubiquitination[1]
146FGLCTGLKKAHRTEFubiquitination[1]
147GLCTGLKKAHRTEFYubiquitination[1]
173SFQNMNSKRKAETWKubiquitination[1]
285NSGVEEIKGHPFFEGubiquitination[1]
367GSIPTYMKAGKL***ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 371 AA 
Protein Sequence
MEEEGLADEE VRLVQKKDTG HIYAMKILRK SDMLEKEQVA HIRAERDILV EADGAWVVKM 60
FYSFQDKRNL YLIMEFLPGG DMMTLLMKKD TLTEEETQFY ISETVLAIDA IHQLGFIHRD 120
IKPDNLLLDA KGHVKLSDFG LCTGLKKAHR TEFYRNLTHN PPSDFSFQNM NSKRKAETWK 180
KNRRQLAYST VGTPDYIAPE VFMQTGYNKL CDWWSLGVIM YEMLIGYPPF CSETPQETYR 240
KVMNWKETLV FPPEVPISEK AKDLILRFCI DSENRIGNSG VEEIKGHPFF EGVDWEHIRE 300
RPAAIPIEIK SIDDTSNFDD FPESDILQPV PNTTEPDYKS KDWVFLNYTY KRFEGLTQRG 360
SIPTYMKAGK L 371 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS