UniProt Accession

 PDCD4_MOUSE; Q61823; P97296; Q3T9A9 

Genbank Protein ID

 D50465; D86344; AB010139; DQ479921; CT010188; AK134366; AK172654; BC055739 

Genbank Nucleotide ID

 BAA09056.1; BAA13072.1; BAA32356.1; ABF51670.1; CAJ18396.1; BAE22118.1; BAE43115.1; AAH55739.1 

Protein Name

 Programmed cell death protein 4 

Protein Synonyms/Alias

 Protein MA-3; Topoisomerase-inhibitor suppressed protein 

Gene Name

 Pdcd4 

Gene Synonyms/Alias

 Ma3; Tis 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
242	DVEKSFDKLLKDLPE	ubiquitination	[1]
245	KSFDKLLKDLPELAL	ubiquitination	[1]
297	QARAALDKATVLLSM	ubiquitination	[1]
306	TVLLSMSKGGKRKDS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. 

Sequence Annotation

 DOMAIN 163 284 MI 1.
 DOMAIN 326 449 MI 2.
 MOTIF 58 64 Nuclear localization signal (Potential).
 MOTIF 70 76 Phosphodegron (By similarity).
 MOTIF 448 454 Nuclear localization signal (Potential).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 67 67 Phosphoserine; by PKB and RPS6KB1 (By
 MOD_RES 76 76 Phosphoserine.
 MOD_RES 78 78 Phosphoserine (By similarity).
 MOD_RES 94 94 Phosphoserine (By similarity).
 MOD_RES 152 152 Phosphotyrosine (By similarity).
 MOD_RES 457 457 Phosphoserine; by PKB (By similarity).  

Keyword

 3D-structure; Acetylation; Apoptosis; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Tumor suppressor; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 469 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007569; P:cell aging; ISS:UniProtKB.
 GO:0043508; P:negative regulation of JUN kinase activity; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 

Interpro

 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3. 

Pfam

 PF02847; MA3 

SMART

 SM00544; MA3 

PROSITE

 PS51366; MI 

PRINTS