CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020734
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytochrome c1, heme protein, mitochondrial 
Protein Synonyms/Alias
 Complex III subunit 4; Complex III subunit IV; Cytochrome b-c1 complex subunit 4; Ubiquinol-cytochrome-c reductase complex cytochrome c1 subunit; Cytochrome c-1 
Gene Name
 Cyc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
177KLSDYFPKPYPNPEAacetylation[1, 2, 3]
177KLSDYFPKPYPNPEAubiquitination[4]
310TYAMKRHKWSVLKSRacetylation[1, 3]
315RHKWSVLKSRKLAYRacetylation[1]
325KLAYRPPK*******acetylation[3]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 This is the heme-containing component of the cytochrome b-c1 complex, which accepts electrons from Rieske protein and transfers electrons to cytochrome c in the mitochondrial respiratory chain (By similarity). 
Sequence Annotation
 DOMAIN 108 209 Cytochrome c.
 METAL 125 125 Iron (heme axial ligand).
 METAL 244 244 Iron (heme axial ligand) (By similarity).
 BINDING 121 121 Heme (covalent).
 BINDING 124 124 Heme (covalent).  
Keyword
 Alternative splicing; Complete proteome; Direct protein sequencing; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Respiratory chain; Transit peptide; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 325 AA 
Protein Sequence
MAAAAASLRR TVLGPRGVGL PGASAPGLLG GARSRQLPLR TPQAVSLSSK SGPSRGRKVM 60
LSALGMLAAG GAGLAVALHS AVSASDLELH PPSYPWSHRG LLSSLDHTSI RRGFQVYKQV 120
CSSCHSMDYV AYRHLVGVCY TEEEAKALAE EVEVQDGPND DGEMFMRPGK LSDYFPKPYP 180
NPEAARAANN GALPPDLSYI VRARHGGEDY VFSLLTGYCE PPTGVSLREG LYFNPYFPGQ 240
AIGMAPPIYT EVLEYDDGTP ATMSQVAKDV ATFLRWASEP EHDHRKRMGL KMLLMMGLLL 300
PLTYAMKRHK WSVLKSRKLA YRPPK 325 
Gene Ontology
 GO:0030054; C:cell junction; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0070469; C:respiratory chain; IEA:UniProtKB-KW.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0022900; P:electron transport chain; IEA:UniProtKB-KW. 
Interpro
 IPR002326; Cyt_c1.
 IPR021157; Cyt_c1_TM_anchor_C.
 IPR009056; Cyt_c_dom. 
Pfam
 PF02167; Cytochrom_C1 
SMART
  
PROSITE
 PS51007; CYTC 
PRINTS
 PR00603; CYTOCHROMEC1.