CPLM-001132

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-001132

UniProt Accession

PP6R2_HUMAN; O75170; A6PVG3; B7Z7T3; Q5U5P3; Q7Z2L2; Q7Z5G5; Q7Z731; Q9UGB9

Genbank Protein ID

AB014585; AK302472; AL096767; AL671545; AL954743; AL096767; AL671545; AL954743; AL096767; AL671545; AL954743; AL096767; AL671545; AL954743; AL954743; AL096767; AL671545; AL954743; AL096767; AL671545; AL954743; AL096767; AL671545; AL954743; AL096767; AL671545; AL671545; AL096767; AL954743; AL671545; AL096767; AL954743; AL671545; AL096767; AL954743; AL671545; AL096767; AL954743; BC000976; BC006568; BC032664; BC041698; BC052995

Genbank Nucleotide ID

BAA31660.2; BAH13719.1; CAO03456.1; CAO03456.1; CAO03456.1; CAO03457.1; CAO03457.1; CAO03457.1; CAO03458.1; CAO03458.1; CAO03458.1; CAO03459.1; CAO03459.1; CAO03459.1; CAO03561.1; CAO03561.1; CAO03561.1; CAO03562.1; CAO03562.1; CAO03562.1; CAO03563.1; CAO03563.1; CAO03563.1; CAO03564.1; CAO03564.1; CAO03564.1; CAO03642.1; CAO03642.1; CAO03642.1; CAO03643.1; CAO03643.1; CAO03643.1; CAO03644.1; CAO03644.1; CAO03644.1; CAO03645.1; CAO03645.1; CAO03645.1; AAH00976.2; AAH06568.1; AAH32664.1; AAH41698.1; AAH52995.1

Protein Name

Serine/threonine-protein phosphatase 6 regulatory subunit 2

Protein Synonyms/Alias

SAPS domain family member 2

Gene Name

PPP6R2

Gene Synonyms/Alias

KIAA0685; PP6R2; SAPS2

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
76	MEEKVRFKYPNTACE	ubiquitination	[1]
449	MVTHLFQKCCLVQRI	ubiquitination	[1]

Reference

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Regulatory subunit of protein phosphatase 6 (PP6). May function as a scaffolding PP6 subunit. Involved in the PP6- mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha.

Sequence Annotation

MOD_RES 289 289 Phosphoserine.

Keyword

Alternative splicing; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

966 AA

Protein Sequence

MFWKFDLNTT SHVDKLLDKE HVTLQELMDE DDILQECKAQ NQKLLDFLCR QQCMEELVSL 60
ITQDPPLDME EKVRFKYPNT ACELLTCDVP QISDRLGGDE SLLSLLYDFL DHEPPLNPLL 120
ASFFSKTIGN LIARKTEQVI TFLKKKDKFI SLVLKHIGTS ALMDLLLRLV SCVEPAGLRQ 180
DVLHWLNEEK VIQRLVELIH PSQDEDRQSN ASQTLCDIVR LGRDQGSQLQ EALEPDPLLT 240
ALESQDCVEQ LLKNMFDGDR TESCLVSGTQ VLLTLLETRR VGTEGLVDSF SQGLERSYAV 300
SSSVLHGIEP RLKDFHQLLL NPPKKKAILT TIGVLEEPLG NARLHGARLM AALLHTNTPS 360
INQELCRLNT MDLLLDLFFK YTWNNFLHFQ VELCIAAILS HAAREERTEA SGSESRVEPP 420
HENGNRSLET PQPAASLPDN TMVTHLFQKC CLVQRILEAW EANDHTQAAG GMRRGNMGHL 480
TRIANAVVQN LERGPVQTHI SEVIRGLPAD CRGRWESFVE ETLTETNRRN TVDLVSTHHL 540
HSSSEDEDIE GAFPNELSLQ QAFSDYQIQQ MTANFVDQFG FNDEEFADQD DNINAPFDRI 600
AEINFNIDAD EDSPSAALFE ACCSDRIQPF DDDEDEDIWE DSDTRCAARV MARPRFGAPH 660
ASESCSKNGP ERGGQDGKAS LEAHRDAPGA GAPPAPGKKE APPVEGDSEG AMWTAVFDEP 720
ANSTPTAPGV VRDVGSSVWA AGTSAPEEKG WAKFTDFQPF CCSESGPRCS SPVDTECSHA 780
EGSRSQGPEK ASQASYFAVS PASPCAWNVC VTRKAPLLAS DSSSSGGSHS EDGDQKAASA 840
MDAVSRGPGR EAPPLPTVAR TEEAVGRVGC ADSRLLSPAC PAPKEVTAAP AVAVPPEATV 900
AITTALSKAG PAIPTPAVSS ALAVAVPLGP IMAVTAAPAM VATLGTVTKD GKTDAPPEGA 960
ALNGPV 966

Gene Ontology

GO:0005737; C:cytoplasm; IDA:HPA.
GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.

Interpro

IPR007587; SAPS.

Pfam

PF04499; SAPS

SMART

PROSITE

PRINTS