| Tag | Content |
|---|
| CPLM ID | CPLM-005238 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tail-specific protease |
Protein Synonyms/Alias | C-terminal-processing peptidase; PRC protein; Protease Re |
Gene Name | prc |
Gene Synonyms/Alias | tsp; b1830; JW1819 |
Created Date | July 27, 2013 |
Organism | Escherichia coli (strain K12) |
NCBI Taxa ID | 83333 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 169 | LNALWDSKVKFDELS | acetylation | [1] | | 308 | DDVVALIKGPKGSKV | acetylation | [1] |
|
Reference | [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli. Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C. Mol Cell. 2013 Jul 25;51(2):265-72. [ PMID: 23830618] |
Functional Description | Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses. |
Sequence Annotation | DOMAIN 238 322 PDZ.
ACT_SITE 452 452 Charge relay system.
ACT_SITE 463 463 Charge relay system (Probable).
ACT_SITE 477 477 Charge relay system. |
Keyword | Cell inner membrane; Cell membrane; Complete proteome; Hydrolase; Membrane; Protease; Reference proteome; Serine protease; Signal. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 682 AA |
Protein Sequence | MNMFFRLTAL AGLLAIAGQT FAVEDITRAD QIPVLKEETQ HATVSERVTS RFTRSHYRQF 60
DLDQAFSAKI FDRYLNLLDY SHNVLLASDV EQFAKKKTEL GDELRSGKLD VFYDLYNLAQ 120
KRRFERYQYA LSVLEKPMDF TGNDTYNLDR SKAPWPKNEA ELNALWDSKV KFDELSLKLT 180
GKTDKEIRET LTRRYKFAIR RLAQTNSEDV FSLAMTAFAR EIDPHTNYLS PRNTEQFNTE 240
MSLSLEGIGA VLQMDDDYTV INSMVAGGPA AKSKAISVGD KIVGVGQTGK PMVDVIGWRL 300
DDVVALIKGP KGSKVRLEIL PAGKGTKTRT VTLTRERIRL EDRAVKMSVK TVGKEKVGVL 360
DIPGFYVGLT DDVKVQLQKL EKQNVSSVII DLRSNGGGAL TEAVSLSGLF IPAGPIVQVR 420
DNNGKVREDS DTDGQVFYKG PLVVLVDRFS ASASEIFAAA MQDYGRALVV GEPTFGKGTV 480
QQYRSLNRIY DQMLRPEWPA LGSVQYTIQK FYRVNGGSTQ RKGVTPDIIM PTGNEETETG 540
EKFEDNALPW DSIDAATYVK SGDLTAFEPE LLKEHNARIA KDPEFQNIMK DIARFNAMKD 600
KRNIVSLNYA VREKENNEDD ATRLARLNER FKREGKPELK KLDDLPKDYQ EPDPYLDETV 660
NIALDLAKLE KARPAEQPAP VK 682 |
Gene Ontology | GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoCyc. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0004175; F:endopeptidase activity; IDA:EcoliWiki. GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW. GO:0030163; P:protein catabolic process; IDA:EcoliWiki. GO:0006508; P:proteolysis; IDA:EcoliWiki. GO:0042493; P:response to drug; EXP:EcoCyc. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |