CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021154
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Tyrosine-protein kinase wzc 
Protein Synonyms/Alias
  
Gene Name
 wzc 
Gene Synonyms/Alias
 STM2116 
Created Date
 July 27, 2013 
Organism
 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
NCBI Taxa ID
 99287 
Lysine Modification
Position
Peptide
Type
References
354RKALEDEKAKLNGRVacetylation[1]
356ALEDEKAKLNGRVTAacetylation[1]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium (By similarity). 
Sequence Annotation
 MOD_RES 568 568 Phosphotyrosine; by autocatalysis (By
 MOD_RES 707 707 Phosphotyrosine (By similarity).
 MOD_RES 709 709 Phosphotyrosine (By similarity).
 MOD_RES 710 710 Phosphotyrosine (By similarity).
 MOD_RES 712 712 Phosphotyrosine (By similarity).
 MOD_RES 714 714 Phosphotyrosine (By similarity).  
Keyword
 ATP-binding; Cell inner membrane; Cell membrane; Complete proteome; Exopolysaccharide synthesis; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 719 AA 
Protein Sequence
MTEKAKQSAA VTGSDEIDIG RLVGTVIEAR WWVLGTTAIF ALCAVIYTFF ATPIYSADAL 60
VQIEQNAGNS LVQDINSALA NKPPASDAEI QLIRSRLVLG KTVDDLDLDI AVTKNTFPLF 120
GAGWERLMGR HNEMVKVTTF TRPETMSGQI FTLKVLGDKR YQLVSDGGFS AQGVVGQPLN 180
KDGVTMRVEA IDARPDTEFT VSKFSTLGMI NNLQNNLTVT ETGKDTGVLS LTFTGEDRDQ 240
IREILNSITR NYLQQDIARK SEEAGKSLAF LAKQLPEVRS RLDVAENKLN AFRQDKDSVD 300
LPLEAKAVLD SMVNIDAQLN ELTFKEAEIS KLFTKAHPAY RTLLEKRKAL EDEKAKLNGR 360
VTAMPKTQQE IVRLTRDVES GQQVYMQLLN KQQELKITEA STVGDVRIVD PAITQPGVLK 420
PKKALIILGS IILGLMLSIV GVLLRSLFNR GIESPQALEE HGISVYASIP LSEWQKARDS 480
VKTIKGIKRY KQSQLLAVGN PTDLAIEAIR SLRTSLHFAM MQAQNNVLML TGVSPSIGKT 540
FVCANLAAVI SQTHKRVLLI DCDMRKGYTH ELLGTNNVDG LSDILAGKGE IASCAKPTAI 600
ANFDLIPRGQ VPPNPSELLM SERFGELIAW ASSRYDLVLI DTPPILAVTD AAIVGRHAGT 660
TLMVARYAVN TLKEVETSLS RFDQNGIQVK GVILNSIFRR ATGYQDYGYY EYEYQSDSK 719 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0030234; F:enzyme regulator activity; IEA:InterPro.
 GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
 GO:0045227; P:capsule polysaccharide biosynthetic process; IEA:InterPro.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
 GO:0050790; P:regulation of catalytic activity; IEA:GOC. 
Interpro
 IPR025669; AAA_dom.
 IPR005702; EPS_synthesis.
 IPR003856; LipoPS_biosynth.
 IPR027417; P-loop_NTPase. 
Pfam
 PF13614; AAA_31
 PF02706; Wzz 
SMART
  
PROSITE
  
PRINTS