UniProt Accession

 SOSSC_HUMAN; Q9NRY2; Q5VWJ7; Q96E04; Q9P090 

Genbank Protein ID

 AF161409; AF161411; AL390067; AL390067; BC013097; BC014881; BC065210 

Genbank Nucleotide ID

 AAF28969.1; AAF28971.2; CAH71934.1; CAH71936.1; AAH13097.1; AAH14881.1; AAH65210.1 

Protein Name

 SOSS complex subunit C 

Protein Synonyms/Alias

 INTS3- and NABP-interacting protein; Sensor of single-strand DNA complex subunit C; Sensor of ssDNA subunit C; SOSS-C; Single-stranded DNA-binding protein-interacting protein 1; SSB-interacting protein 1; hSSBIP1 

Gene Name

 INIP 

Gene Synonyms/Alias

 C9orf80; SSBIP1; HSPC043; HSPC291 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
28	ELDKEKRKLLMQNQS	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single- stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination- dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; DNA damage; DNA repair; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 104 AA 

Protein Sequence

Gene Ontology

 GO:0070876; C:SOSS complex; IDA:UniProtKB.
 GO:0006281; P:DNA repair; IMP:UniProtKB.
 GO:0010212; P:response to ionizing radiation; IMP:UniProtKB. 

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PRINTS