UniProt Accession

 CLD2_HUMAN; P57739; B2R6B9 

Genbank Protein ID

 AF250558; AY358474; AK312515; AF177340; AK075371; AK075405; AL158821; CH471120; CH471120; BC014424; BC071747 

Genbank Nucleotide ID

 AAF98151.1; AAQ88838.1; BAG35416.1; AAG17984.1; BAC11575.1; BAG52130.1; CAD23055.1; EAX02730.1; EAX02731.1; AAH14424.1; AAH71747.1 

Protein Name

 Claudin-2 

Protein Synonyms/Alias

 SP82 

Gene Name

 CLDN2 

Gene Synonyms/Alias

 PSEC0059; SP82; UNQ705/PRO1356 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
218	PGQPPKVKSEFNSYS	sumoylation	[1]

Reference

 [1] SUMOylation of claudin-2.
 Van Itallie CM, Mitic LL, Anderson JM.
 Ann N Y Acad Sci. 2012 Jul;1258:60-4. [PMID: 22731716] 

Functional Description

 Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity (By similarity). 

Sequence Annotation

 REGION 229 230 Interactions with TJP1, TJP2 and TJP3 (By
 DISULFID 54 64
 CROSSLNK 218 218 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Cell junction; Cell membrane; Complete proteome; Disulfide bond; Isopeptide bond; Membrane; Reference proteome; Tight junction; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 230 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005923; C:tight junction; ISS:UniProtKB.
 GO:0042802; F:identical protein binding; ISS:UniProtKB.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0016338; P:calcium-independent cell-cell adhesion; ISS:UniProtKB. 

Interpro

 IPR006187; Claudin.
 IPR005411; Claudin2.
 IPR017974; Claudin_CS.
 IPR004031; PMP22/EMP/MP20/Claudin. 

Pfam

 PF00822; PMP22_Claudin 

SMART

  

PROSITE

 PS01346; CLAUDIN 

PRINTS

 PR01077; CLAUDIN.
 PR01589; CLAUDIN2.