CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011677
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neuroblast differentiation-associated protein AHNAK 
Protein Synonyms/Alias
 Desmoyokin 
Gene Name
 AHNAK 
Gene Synonyms/Alias
 PM227 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
128YQRIYTTKIKPRLKSubiquitination[1]
130RIYTTKIKPRLKSEDubiquitination[1]
134TKIKPRLKSEDGVEGubiquitination[1, 2, 3, 4]
181DISSPEFKIKIPRHEubiquitination[1]
263SGVNVNAKGLDLGGRubiquitination[1, 4, 5]
344SVGHKGGKPGLTIQAubiquitination[4]
371EGLEGKLKGPQITGPubiquitination[4]
530PGVQGDVKGPQVALKubiquitination[1, 4]
663DISISGPKVNVEAPDubiquitination[1]
679NLEGLGGKLKGPDVKacetylation[6]
679NLEGLGGKLKGPDVKubiquitination[1]
712HVKGTKVKGEYDVTVubiquitination[1]
756MPKMKMPKFSVPGFKubiquitination[5]
784DVDISGPKIDVTAPDubiquitination[1]
800SIEEPEGKLKGPKFKubiquitination[1, 4]
807KLKGPKFKMPEMNIKubiquitination[5]
833HLKGPNVKGEYDVTMubiquitination[1]
848PKVESEIKVPDVELKubiquitination[1]
855KVPDVELKSAKMDIDubiquitination[4]
884MPKMKMPKFSMPGFKacetylation[6, 7, 8]
884MPKMKMPKFSMPGFKubiquitination[1, 5, 9, 10]
891KFSMPGFKAEGPEVDacetylation[11]
891KFSMPGFKAEGPEVDsumoylation[12]
891KFSMPGFKAEGPEVDubiquitination[1, 2, 4, 5]
912DVDISGPKVGVEVPDubiquitination[1]
928NIEGPEGKLKGPKFKubiquitination[1, 4]
942KMPEMNIKAPKISMPacetylation[11]
942KMPEMNIKAPKISMPubiquitination[4, 5]
961HMKGPKVKGEYDMTVubiquitination[1]
997QGPDWNLKMPKIKMPubiquitination[4]
1005MPKIKMPKFSMPSLKubiquitination[5]
1012KFSMPSLKGEGPEFDubiquitination[1, 4]
1033NVDISAPKVDTNAPDubiquitination[1]
1049SLEGPEGKLKGPKFKacetylation[6]
1049SLEGPEGKLKGPKFKubiquitination[1, 4]
1056KLKGPKFKMPEMHFRubiquitination[4]
1077PDVDLDLKGPKMKGNubiquitination[4]
1111RGPKVDIKAPDVEGQubiquitination[1, 4]
1140KFSMPSLKGEGPEVDubiquitination[1, 4]
1161DVVVSGPKVDIEAPDubiquitination[1]
1177SLEGPEGKLKGPKFKubiquitination[1, 4]
1191KMPEMHFKTPKISMPubiquitination[5]
1205PDVDLHLKGPKVKGDubiquitination[1, 2, 4]
1210HLKGPKVKGDVDVSVubiquitination[1, 4]
1225PKVEGEMKVPDVEIKubiquitination[1]
1232KVPDVEIKGPKMDIDubiquitination[1]
1268KFSMPGFKGEGREVDacetylation[6, 11]
1280EVDVNLPKADIDVSGacetylation[6]
1289DIDVSGPKVDVEVPDubiquitination[1]
1305SLEGPEGKLKGPKFKacetylation[6]
1305SLEGPEGKLKGPKFKubiquitination[1, 4]
1353PEVEGEMKVPDVDIKubiquitination[1]
1360KVPDVDIKGPKVDISubiquitination[1, 2, 4]
1363DVDIKGPKVDISAPDubiquitination[1]
1396KFSMPGFKGEGPEVDubiquitination[1, 4, 5]
1433NIEGPDAKLKGPKFKubiquitination[4]
1450EMSIKPQKISIPDVGubiquitination[4]
1461PDVGLHLKGPKMKGDubiquitination[9, 10]
1464GLHLKGPKMKGDYDVubiquitination[9, 10]
1481PKVEGEIKAPDVDIKubiquitination[1]
1524KFSMPGFKGEGPEVDubiquitination[4]
1536EVDMNLPKADLGVSGubiquitination[1]
1545DLGVSGPKVDIDVPDubiquitination[1]
1561NLEAPEGKLKGPKFKacetylation[6]
1589PDVGLNLKAPKLKTDubiquitination[4]
1616KGPEIDVKAPKMDVNubiquitination[1]
1619EIDVKAPKMDVNVGDubiquitination[1]
1635DIEGPEGKLKGPKFKacetylation[6]
1635DIEGPEGKLKGPKFKubiquitination[1]
1763DIEGPEGKLKGSKFKubiquitination[1]
1911KLKGPKFKMPDMHFKacetylation[8]
1918KMPDMHFKAPKISMPubiquitination[5]
2074EVDVNLPKADVVVSGubiquitination[1]
2132HLKGPKVKGDVDVSLubiquitination[5]
2257KFSMPGFKGEGPEVDacetylation[6]
2257KFSMPGFKGEGPEVDmethylation[13]
2257KFSMPGFKGEGPEVDubiquitination[4]
2322PDVDFNLKGPKIKGDubiquitination[1]
2325DFNLKGPKIKGDVDVubiquitination[1]
2327NLKGPKIKGDVDVSAubiquitination[1]
2342PKLEGELKGPELDVKacetylation[6]
2368AVEGPNGKWKTPKFKubiquitination[1, 4]
2463PDVDLNLKGPKIKGDubiquitination[4]
2561NIEGPEGKLKGPKLKacetylation[6]
2561NIEGPEGKLKGPKLKubiquitination[1]
2578EMNIKAPKISMPDFDubiquitination[5]
2589PDFDLHLKGPKVKGDubiquitination[4, 5]
2609PKVEGDLKGPEVDIKacetylation[8]
2609PKVEGDLKGPEVDIKubiquitination[1, 4]
2616KGPEVDIKGPKVDINubiquitination[1]
2652KFSMPGFKGEGPDGDubiquitination[5]
2706EMNIKAPKISMPDIDubiquitination[1]
2717PDIDLNLKGPKVKGDubiquitination[1, 4]
2720DLNLKGPKVKGDVDVubiquitination[4]
2773MPKIKMPKISMPGFKubiquitination[5]
2780KISMPGFKGEGPDVDacetylation[6]
2780KISMPGFKGEGPDVDubiquitination[1, 4]
2822EGKWKSPKFKMPEMHubiquitination[1]
2824KWKSPKFKMPEMHFKubiquitination[1]
2865PKVEGDLKGPEVDLKacetylation[6]
2865PKVEGDLKGPEVDLKubiquitination[1, 4]
2872KGPEVDLKGPKVDIDubiquitination[1]
2945NIEGPEGKLKGPKFKacetylation[6]
2973PDFDLHLKGPKVKGDubiquitination[4]
2993PKVEGDLKGPEVDIRubiquitination[1, 4]
3029MPKVKMPKFSMPGFKubiquitination[5]
3036KFSMPGFKGEGPDVDacetylation[6, 11]
3036KFSMPGFKGEGPDVDubiquitination[1, 2, 4, 5]
3073NIEGPEGKLKGPKFKacetylation[6]
3164KISMPGFKGEGPEVDacetylation[6, 11]
3164KISMPGFKGEGPEVDubiquitination[1, 4]
3201NIEGPDAKLKGPKFKacetylation[6]
3201NIEGPDAKLKGPKFKubiquitination[1, 4]
3218EMNIKAPKISMPDLDubiquitination[1]
3229PDLDLNLKGPKMKGEubiquitination[2, 4]
3256KGPALDIKGPKIDVDubiquitination[4]
3303PEIDLNLKGSKLKGDubiquitination[4]
3317DVDVSGPKLEGDIKAubiquitination[14]
3323PKLEGDIKAPSLDIKubiquitination[4]
3330KAPSLDIKGPEVDVSubiquitination[1, 2, 4]
3356KSRFKLPKFNFSGSKubiquitination[5]
3363KFNFSGSKVQTPEVDubiquitination[1, 2, 4, 5]
3372QTPEVDVKGKKPDIDubiquitination[4]
3397PDVEVQGKVKGSKFKubiquitination[1]
3404KVKGSKFKMPFLSISubiquitination[5]
3452KGPKVDIKAPEVNLNubiquitination[1, 2, 4]
3473HGPDWNLKMPKMKMPubiquitination[4]
3481MPKMKMPKFSVSGLKubiquitination[5]
3488KFSVSGLKAEGPDVAubiquitination[1, 4, 5]
3573PKLEGDLKGPEVDIKubiquitination[1]
3616KFSMPGFKGEGPEVDubiquitination[4]
3681PDFDLNLKGPKMKGDubiquitination[4]
3727NIEGSEGKFKGPKFKacetylation[6]
3727NIEGSEGKFKGPKFKubiquitination[5]
3758DLNLKGPKVKGDVDVubiquitination[4]
3760NLKGPKVKGDVDVSLubiquitination[4]
3769DVDVSLPKMEGDLKGubiquitination[4]
3910QVPDLDIKGPKVDINubiquitination[1, 4]
4111DIHGPEGKLKGPKFKacetylation[6]
4118KLKGPKFKMPDLHLKubiquitination[4, 5]
4125KMPDLHLKAPKISMPubiquitination[4]
4128DLHLKAPKISMPEVDmethylation[13]
4139PEVDLNLKGPKMKGDmethylation[13]
4223DLDVSGPKVDIDVPDubiquitination[1]
4239NIEGPDAKLKGPKFKacetylation[6]
4367SIEGPDAKLKGPKFKacetylation[6]
4395PDIDFNLKGPKVKGDubiquitination[4]
4489PKVESDLKGPEVDIEubiquitination[1]
4501DIEGPEGKLKGPKFKacetylation[6]
4529SDIDLNLKGPKIKGDubiquitination[4]
4543DMDISVPKLEGDLKGubiquitination[1]
4687DIDVSGPKVDVDVPDubiquitination[1]
4794KFSMPGFKGEGPDVDubiquitination[1, 4, 5]
4806DVDVSLPKADIDVSGubiquitination[1]
4831NIEGPDAKLKGPKFKacetylation[6]
4859PDVDLDLKGPKVKGDubiquitination[1, 4]
4864DLKGPKVKGDFDVSVubiquitination[5]
4879PKVEGTLKGPEVDLKubiquitination[1, 4, 5]
4886KGPEVDLKGPRLDFEubiquitination[2, 4]
4898DFEGPDAKLSGPSLKubiquitination[1, 4, 5]
4905KLSGPSLKMPSLEISubiquitination[1, 2, 4, 5]
4926PDVDLHLKAPKIGFSubiquitination[4]
4936KIGFSGPKLEGGEVDubiquitination[1, 4]
4945EGGEVDLKGPKVEAPubiquitination[1, 2, 4]
4971NIEGPDVKIPKFKKPubiquitination[1]
4979IPKFKKPKFGFGAKSubiquitination[5]
4985PKFGFGAKSPKADIKubiquitination[2]
4992KSPKADIKSPSLDVTubiquitination[1, 2, 3, 4]
5087TKKTMFGKMYFPDVEubiquitination[1, 4, 5]
5137HVEGLDIKAKAPKVKubiquitination[1, 2, 4]
5144KAKAPKVKMPDVDISubiquitination[1]
5160PKIEGDLKGPKVQANubiquitination[4]
5181NIEGLDAKVKTPSFGubiquitination[1, 2, 4]
5183EGLDAKVKTPSFGISubiquitination[1, 4]
5204PDVNVNLKGPKIKGDubiquitination[1, 2, 4]
5209NLKGPKIKGDVPSVGubiquitination[1, 4]
5235EAKIKFPKFSMPKIGubiquitination[5]
5272DLRGPDVKLEGPDVSubiquitination[1]
5281EGPDVSLKGPGVDLPubiquitination[1, 4]
5307PDLDLNLKGPSLKGDubiquitination[4]
5312NLKGPSLKGDLDASVubiquitination[1, 4, 5]
5337NLSGVGGKMQVGGDGubiquitination[5]
5346QVGGDGVKVPGIDATubiquitination[4]
5443PGVDVNLKGPRISAPubiquitination[4]
5460DFNLEGPKVKGSLGAubiquitination[1]
5524QISGPEIKGGLKGSEubiquitination[1, 4]
5562SDFGINLKGPKIKGGubiquitination[4]
5598KGSGGEWKGPQVSSAubiquitination[4]
5623GLHFSGPKVEGGVKGacetylation[6]
5623GLHFSGPKVEGGVKGubiquitination[5]
5629PKVEGGVKGGQIGLQubiquitination[1, 2, 4]
5665FPKMKIPKFTFSGREubiquitination[5]
5725NFSKPKGKGGVTGSPubiquitination[1, 4, 5]
5740EASISGSKGDLKSSKubiquitination[1, 4]
5744SGSKGDLKSSKASLGubiquitination[1]
5747KGDLKSSKASLGSLEubiquitination[1, 2, 4]
5765EAEASSPKGKFSLFKacetylation[15]
5767EASSPKGKFSLFKSKubiquitination[2]
5772KGKFSLFKSKKPRHRacetylation[15]
5774KFSLFKSKKPRHRSNacetylation[15]
5821KGKHGKLKFGTFGGLacetylation[6]
5821KGKHGKLKFGTFGGLubiquitination[5]
5831TFGGLGSKSKGHYEVubiquitination[2]
5858SGVSLASKKSRLSSSubiquitination[4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [7] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [8] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [9] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [10] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [11] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [12] Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif.
 Matic I, Schimmel J, Hendriks IA, van Santen MA, van de Rijke F, van Dam H, Gnad F, Mann M, Vertegaal AC.
 Mol Cell. 2010 Aug 27;39(4):641-52. [PMID: 20797634]
 [13] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [14] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [15] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 
Functional Description
 May be required for neuronal cell differentiation. 
Sequence Annotation
 DOMAIN 9 90 PDZ.
 MOTIF 4971 4979 Nuclear localization signal (Potential).
 MOTIF 5019 5027 Nuclear localization signal (Potential).
 MOTIF 5034 5039 Nuclear localization signal (Potential).
 MOTIF 5706 5716 Nuclear localization signal (Potential).
 MOTIF 5772 5779 Nuclear localization signal (Potential).
 MOD_RES 41 41 Phosphoserine.
 MOD_RES 93 93 Phosphoserine.
 MOD_RES 101 101 Phosphothreonine.
 MOD_RES 135 135 Phosphoserine.
 MOD_RES 177 177 Phosphoserine.
 MOD_RES 210 210 Phosphoserine.
 MOD_RES 212 212 Phosphoserine.
 MOD_RES 216 216 Phosphoserine.
 MOD_RES 490 490 Phosphothreonine.
 MOD_RES 511 511 Phosphoserine.
 MOD_RES 559 559 Phosphoserine.
 MOD_RES 570 570 Phosphoserine.
 MOD_RES 793 793 Phosphoserine.
 MOD_RES 1068 1068 Phosphoserine.
 MOD_RES 1192 1192 Phosphothreonine.
 MOD_RES 1286 1286 Phosphoserine.
 MOD_RES 1986 1986 Phosphothreonine.
 MOD_RES 2181 2181 Phosphothreonine.
 MOD_RES 2309 2309 Phosphothreonine.
 MOD_RES 2397 2397 Phosphoserine.
 MOD_RES 2670 2670 Phosphoserine.
 MOD_RES 2798 2798 Phosphoserine.
 MOD_RES 2832 2832 Phosphothreonine.
 MOD_RES 2845 2845 Phosphothreonine.
 MOD_RES 3054 3054 Phosphoserine.
 MOD_RES 3409 3409 Phosphoserine.
 MOD_RES 3412 3412 Phosphoserine.
 MOD_RES 3426 3426 Phosphoserine.
 MOD_RES 3716 3716 Phosphothreonine.
 MOD_RES 3836 3836 Phosphoserine.
 MOD_RES 4092 4092 Phosphoserine.
 MOD_RES 4100 4100 Phosphothreonine.
 MOD_RES 4220 4220 Phosphoserine.
 MOD_RES 4430 4430 Phosphothreonine.
 MOD_RES 4516 4516 Phosphoserine.
 MOD_RES 4684 4684 Phosphoserine.
 MOD_RES 4766 4766 Phosphothreonine.
 MOD_RES 4812 4812 Phosphoserine.
 MOD_RES 4903 4903 Phosphoserine.
 MOD_RES 4960 4960 Phosphoserine.
 MOD_RES 4986 4986 Phosphoserine.
 MOD_RES 4993 4993 Phosphoserine.
 MOD_RES 5009 5009 Phosphothreonine.
 MOD_RES 5077 5077 Phosphoserine.
 MOD_RES 5099 5099 Phosphoserine.
 MOD_RES 5110 5110 Phosphoserine.
 MOD_RES 5125 5125 Phosphoserine.
 MOD_RES 5332 5332 Phosphoserine.
 MOD_RES 5386 5386 Phosphoserine.
 MOD_RES 5400 5400 Phosphoserine.
 MOD_RES 5415 5415 Phosphothreonine.
 MOD_RES 5448 5448 Phosphoserine.
 MOD_RES 5552 5552 Phosphoserine.
 MOD_RES 5620 5620 Phosphoserine.
 MOD_RES 5731 5731 Phosphoserine.
 MOD_RES 5739 5739 Phosphoserine.
 MOD_RES 5749 5749 Phosphoserine.
 MOD_RES 5752 5752 Phosphoserine.
 MOD_RES 5763 5763 Phosphoserine.
 MOD_RES 5780 5780 Phosphoserine.
 MOD_RES 5782 5782 Phosphoserine.
 MOD_RES 5790 5790 Phosphoserine.
 MOD_RES 5793 5793 Phosphoserine.
 MOD_RES 5794 5794 Phosphothreonine.
 MOD_RES 5824 5824 Phosphothreonine.
 MOD_RES 5830 5830 Phosphoserine.
 MOD_RES 5841 5841 Phosphoserine.
 MOD_RES 5857 5857 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 5890 AA 
Protein Sequence
MEKEETTREL LLPNWQGSGS HGLTIAQRDD GVFVQEVTQN SPAARTGVVK EGDQIVGATI 60
YFDNLQSGEV TQLLNTMGHH TVGLKLHRKG DRSPEPGQTW TREVFSSCSS EVVLSGDDEE 120
YQRIYTTKIK PRLKSEDGVE GDLGETQSRT ITVTRRVTAY TVDVTGREGA KDIDISSPEF 180
KIKIPRHELT EISNVDVETQ SGKTVIRLPS GSGAASPTGS AVDIRAGAIS ASGPELQGAG 240
HSKLQVTMPG IKVGGSGVNV NAKGLDLGGR GGVQVPAVDI SSSLGGRAVE VQGPSLESGD 300
HGKIKFPTMK VPKFGVSTGR EGQTPKAGLR VSAPEVSVGH KGGKPGLTIQ APQLEVSVPS 360
ANIEGLEGKL KGPQITGPSL EGDLGLKGAK PQGHIGVDAS APQIGGSITG PSVEVQAPDI 420
DVQGPGSKLN VPKMKVPKFS VSGAKGEETG IDVTLPTGEV TVPGVSGDVS LPEIATGGLE 480
GKMKGTKVKT PEMIIQKPKI SMQDVDLSLG SPKLKGDIKV SAPGVQGDVK GPQVALKGSR 540
VDIETPNLEG TLTGPRLGSP SGKTGTCRIS MSEVDLNVAA PKVKGGVDVT LPRVEGKVKV 600
PEVDVRGPKV DVSAPDVEAH GPEWNLKMPK MKMPTFSTPG AKGEGPDVHM TLPKGDISIS 660
GPKVNVEAPD VNLEGLGGKL KGPDVKLPDM SVKTPKISMP DVDLHVKGTK VKGEYDVTVP 720
KLEGELKGPK VDIDAPDVDV HGPDWHLKMP KMKMPKFSVP GFKAEGPEVD VNLPKADVDI 780
SGPKIDVTAP DVSIEEPEGK LKGPKFKMPE MNIKVPKISM PDVDLHLKGP NVKGEYDVTM 840
PKVESEIKVP DVELKSAKMD IDVPDVEVQG PDWHLKMPKM KMPKFSMPGF KAEGPEVDVN 900
LPKADVDISG PKVGVEVPDV NIEGPEGKLK GPKFKMPEMN IKAPKISMPD VDLHMKGPKV 960
KGEYDMTVPK LEGDLKGPKV DVSAPDVEMQ GPDWNLKMPK IKMPKFSMPS LKGEGPEFDV 1020
NLSKANVDIS APKVDTNAPD LSLEGPEGKL KGPKFKMPEM HFRAPKMSLP DVDLDLKGPK 1080
MKGNVDISAP KIEGEMQVPD VDIRGPKVDI KAPDVEGQGL DWSLKIPKMK MPKFSMPSLK 1140
GEGPEVDVNL PKADVVVSGP KVDIEAPDVS LEGPEGKLKG PKFKMPEMHF KTPKISMPDV 1200
DLHLKGPKVK GDVDVSVPKV EGEMKVPDVE IKGPKMDIDA PDVEVQGPDW HLKMPKMKMP 1260
KFSMPGFKGE GREVDVNLPK ADIDVSGPKV DVEVPDVSLE GPEGKLKGPK FKMPEMHFKA 1320
PKISMPDVDL NLKGPKLKGD VDVSLPEVEG EMKVPDVDIK GPKVDISAPD VDVHGPDWHL 1380
KMPKVKMPKF SMPGFKGEGP EVDVKLPKAD VDVSGPKMDA EVPDVNIEGP DAKLKGPKFK 1440
MPEMSIKPQK ISIPDVGLHL KGPKMKGDYD VTVPKVEGEI KAPDVDIKGP KVDINAPDVE 1500
VHGPDWHLKM PKVKMPKFSM PGFKGEGPEV DMNLPKADLG VSGPKVDIDV PDVNLEAPEG 1560
KLKGPKFKMP SMNIQTHKIS MPDVGLNLKA PKLKTDVDVS LPKVEGDLKG PEIDVKAPKM 1620
DVNVGDIDIE GPEGKLKGPK FKMPEMHFKA PKISMPDVDL HLKGPKVKGD MDVSVPKVEG 1680
EMKVPDVDIK GPKVDIDAPD VEVHDPDWHL KMPKMKMPKF SMPGFKAEGP EVDVNLPKAD 1740
IDVSGPSVDT DAPDLDIEGP EGKLKGSKFK MPKLNIKAPK VSMPDVDLNL KGPKLKGEID 1800
ASVPELEGDL RGPQVDVKGP FVEAEVPDVD LECPDAKLKG PKFKMPEMHF KAPKISMPDV 1860
DLHLKGPKVK GDADVSVPKL EGDLTGPSVG VEVPDVELEC PDAKLKGPKF KMPDMHFKAP 1920
KISMPDVDLH LKGPKVKGDV DVSVPKLEGD LTGPSVGVEV PDVELECPDA KLKGPKFKMP 1980
EMHFKTPKIS MPDVDLHLKG PKVKGDMDVS VPKVEGEMKV PDVDIKGPKM DIDAPDVDVH 2040
GPDWHLKMPK MKMPKFSMPG FKAEGPEVDV NLPKADVVVS GPKVDVEVPD VSLEGPEGKL 2100
KGPKLKMPEM HFKAPKISMP DVDLHLKGPK VKGDVDVSLP KLEGDLTGPS VDVEVPDVEL 2160
ECPDAKLKGP KFKMPEMHFK TPKISMPDVN LNLKGPKVKG DMDVSVPKVE GEMKVPDVDI 2220
RGPKVDIDAP DVDVHGPDWH LKMPKMKMPK FSMPGFKGEG PEVDVNLPKA DVDVSGPKVD 2280
VEVPDVSLEG PEGKLKGPKF KMPEMHFKTP KISMPDVDFN LKGPKIKGDV DVSAPKLEGE 2340
LKGPELDVKG PKLDADMPEV AVEGPNGKWK TPKFKMPDMH FKAPKISMPD LDLHLKSPKA 2400
KGEVDVDVPK LEGDLKGPHV DVSGPDIDIE GPEGKLKGPK FKMPDMHFKA PNISMPDVDL 2460
NLKGPKIKGD VDVSVPEVEG KLEVPDMNIR GPKVDVNAPD VQAPDWHLKM PKMKMPKFSM 2520
PGFKAEGPEV DVNLPKADVD ISGPKVDIEG PDVNIEGPEG KLKGPKLKMP EMNIKAPKIS 2580
MPDFDLHLKG PKVKGDVDVS LPKVEGDLKG PEVDIKGPKV DINAPDVGVQ GPDWHLKMPK 2640
VKMPKFSMPG FKGEGPDGDV KLPKADIDVS GPKVDIEGPD VNIEGPEGKL KGPKFKMPEM 2700
NIKAPKISMP DIDLNLKGPK VKGDVDVSLP KVEGDLKGPE VDIKGPKVDI DAPDVDVHGP 2760
DWHLKMPKIK MPKISMPGFK GEGPDVDVNL PKADIDVSGP KVDVECPDVN IEGPEGKWKS 2820
PKFKMPEMHF KTPKISMPDI DLNLTGPKIK GDVDVTGPKV EGDLKGPEVD LKGPKVDIDV 2880
PDVNVQGPDW HLKMPKMKMP KFSMPGFKAE GPEVDVNLPK ADVDVSGPKV DVEGPDVNIE 2940
GPEGKLKGPK FKMPEMNIKA PKIPMPDFDL HLKGPKVKGD VDISLPKVEG DLKGPEVDIR 3000
GPQVDIDVPD VGVQGPDWHL KMPKVKMPKF SMPGFKGEGP DVDVNLPKAD LDVSGPKVDI 3060
DVPDVNIEGP EGKLKGPKFK MPEMNIKAPK ISMPDIDLNL KGPKVKGDMD VSLPKVEGDM 3120
KVPDVDIKGP KVDINAPDVD VQGPDWHLKM PKIKMPKISM PGFKGEGPEV DVNLPKADLD 3180
VSGPKVDVDV PDVNIEGPDA KLKGPKFKMP EMNIKAPKIS MPDLDLNLKG PKMKGEVDVS 3240
LANVEGDLKG PALDIKGPKI DVDAPDIDIH GPDAKLKGPK LKMPDMHVNM PKISMPEIDL 3300
NLKGSKLKGD VDVSGPKLEG DIKAPSLDIK GPEVDVSGPK LNIEGKSKKS RFKLPKFNFS 3360
GSKVQTPEVD VKGKKPDIDI TGPKVDINAP DVEVQGKVKG SKFKMPFLSI SSPKVSMPDV 3420
ELNLKSPKVK GDLDIAGPNL EGDFKGPKVD IKAPEVNLNA PDVDVHGPDW NLKMPKMKMP 3480
KFSVSGLKAE GPDVAVDLPK GDINIEGPSM NIEGPDLNVE GPEGGLKGPK FKMPDMNIKA 3540
PKISMPDIDL NLKGPKVKGD VDISLPKLEG DLKGPEVDIK GPKVDINAPD VDVHGPDWHL 3600
KMPKVKMPKF SMPGFKGEGP EVDVTLPKAD IDISGPNVDV DVPDVNIEGP DAKLKGPKFK 3660
MPEMNIKAPK ISMPDFDLNL KGPKMKGDVV VSLPKVEGDL KGPEVDIKGP KVDIDTPDIN 3720
IEGSEGKFKG PKFKIPEMHL KAPKISMPDI DLNLKGPKVK GDVDVSLPKM EGDLKGPEVD 3780
IKGPKVDINA PDVDVQGPDW HLKMPKVKMP KFSMPGFKGE GPDVDVNLPK ADLDVSGPKV 3840
DIDVPDVNIE GPEGKLKGPK FKMPEMNIKA PKISMPDIDL NLKGPKVKGD MDVSLPKVEG 3900
DMQVPDLDIK GPKVDINAPD VDVRGPDWHL KMPKIKMPKI SMPGFKGEGP EVDVNLPKAD 3960
LDVSGPKVDV DVPDVNIEGP DAKLKGPKFK MPEMNIKAPK ISMPDFDLHL KGPKVKGDVD 4020
VSLPKMEGDL KAPEVDIKGP KVDIDAPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPEV 4080
DVNLPKADID VSGPKVDIDT PDIDIHGPEG KLKGPKFKMP DLHLKAPKIS MPEVDLNLKG 4140
PKMKGDVDVS LPKVEGDLKG PEVDIKGPKV DIDVPDVDVQ GPDWHLKMPK VKMPKFSMPG 4200
FKGEGPDVDV NLPKADLDVS GPKVDIDVPD VNIEGPDAKL KGPKFKMPEM NIKAPKISMP 4260
DFDLHLKGPK VKGDVDVSLP KVEGDLKGPE VDIKGPKVDI DAPDVDVHGP DWHLKMPKVK 4320
MPKFSMPGFK GEGPDVDVTL PKADIEISGP KVDIDAPDVS IEGPDAKLKG PKFKMPEMNI 4380
KAPKISMPDI DFNLKGPKVK GDVDVSLPKV EGDLKGPEID IKGPSLDIDT PDVNIEGPEG 4440
KLKGPKFKMP EMNIKAPKIS MPDFDLHLKG PKVKGDVDVS LPKVESDLKG PEVDIEGPEG 4500
KLKGPKFKMP DVHFKSPQIS MSDIDLNLKG PKIKGDMDIS VPKLEGDLKG PKVDVKGPKV 4560
GIDTPDIDIH GPEGKLKGPK FKMPDLHLKA PKISMPEVDL NLKGPKVKGD MDISLPKVEG 4620
DLKGPEVDIR DPKVDIDVPD VDVQGPDWHL KMPKVKMPKF SMPGFKGEGP DVDVNLPKAD 4680
IDVSGPKVDV DVPDVNIEGP DAKLKGPKFK MPEMSIKAPK ISMPDIDLNL KGPKVKGDVD 4740
VTLPKVEGDL KGPEADIKGP KVDINTPDVD VHGPDWHLKM PKVKMPKFSM PGFKGEGPDV 4800
DVSLPKADID VSGPKVDVDI PDVNIEGPDA KLKGPKFKMP EINIKAPKIS IPDVDLDLKG 4860
PKVKGDFDVS VPKVEGTLKG PEVDLKGPRL DFEGPDAKLS GPSLKMPSLE ISAPKVTAPD 4920
VDLHLKAPKI GFSGPKLEGG EVDLKGPKVE APSLDVHMDS PDINIEGPDV KIPKFKKPKF 4980
GFGAKSPKAD IKSPSLDVTV PEAELNLETP EISVGGKGKK SKFKMPKIHM SGPKIKAKKQ 5040
GFDLNVPGGE IDASLKAPDV DVNIAGPDAA LKVDVKSPKT KKTMFGKMYF PDVEFDIKSP 5100
KFKAEAPLPS PKLEGELQAP DLELSLPAIH VEGLDIKAKA PKVKMPDVDI SVPKIEGDLK 5160
GPKVQANLGA PDINIEGLDA KVKTPSFGIS APQVSIPDVN VNLKGPKIKG DVPSVGLEGP 5220
DVDLQGPEAK IKFPKFSMPK IGIPGVKMEG GGAEVHAQLP SLEGDLRGPD VKLEGPDVSL 5280
KGPGVDLPSV NLSMPKVSGP DLDLNLKGPS LKGDLDASVP SMKVHAPGLN LSGVGGKMQV 5340
GGDGVKVPGI DATTKLNVGA PDVTLRGPSL QGDLAVSGDI KCPKVSVGAP DLSLEASEGS 5400
IKLPKMKLPQ FGISTPGSDL HVNAKGPQVS GELKGPGVDV NLKGPRISAP NVDFNLEGPK 5460
VKGSLGATGE IKGPTVGGGL PGIGVQGLEG NLQMPGIKSS GCDVNLPGVN VKLPTGQISG 5520
PEIKGGLKGS EVGFHGAAPD ISVKGPAFNM ASPESDFGIN LKGPKIKGGA DVSGGVSAPD 5580
ISLGEGHLSV KGSGGEWKGP QVSSALNLDT SKFAGGLHFS GPKVEGGVKG GQIGLQAPGL 5640
SVSGPQGHLE SGSGKVTFPK MKIPKFTFSG RELVGREMGV DVHFPKAEAS IQAGAGDGEW 5700
EESEVKLKKS KIKMPKFNFS KPKGKGGVTG SPEASISGSK GDLKSSKASL GSLEGEAEAE 5760
ASSPKGKFSL FKSKKPRHRS NSFSDEREFS GPSTPTGTLE FEGGEVSLEG GKVKGKHGKL 5820
KFGTFGGLGS KSKGHYEVTG SDDETGKLQG SGVSLASKKS RLSSSSSNDS GNKVGIQLPE 5880
VELSVSTKKE 5890 
Gene Ontology
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0007399; P:nervous system development; NAS:UniProtKB. 
Interpro
 IPR001478; PDZ. 
Pfam
  
SMART
 SM00228; PDZ 
PROSITE
 PS50106; PDZ 
PRINTS